SURGICAL PATHOLOGY ROTATION

1. Duration
2. Training goals and objectives
3. Overview
4. Service
5. Organization of Service
   1. In-House Service
   2. Frozen Section
   3. "Hot Seat" Service
   4. Submitted Surgicals
   5. Referral of Pathology Material to Other Centers
   6. Laboratory of Pathology Consultations Policy
6. Telephone Notification of Clinical Staff
   Regarding Unexpected Pathologic Findings
7. Back to the Main Manual

SURGICAL PATHOLOGY

A. Duration

• 4 months - Submitted Service
• 4 months - In House Service
• 4 months - Hot Seat Service
• 1 month - Children's Nat. Medical Center (see extramural rotations)
• 1 month - Outside Surgical Pathology (see extramural rotations)

Frozen Section Service is covered during both Surgical Pathology and Autopsy rotations. Integrated Training at NIH includes: Dermatopathology, Electron Microscopy, Hematopathology (in addition to required one month concentrated rotation), Immunopathology, Lab Informatics, Lab Management, Neuropathology, Pediatric Pathology, and Quality Improvement. Refer to section on integrated training for more details.

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B. Training goals and objectives

Overall Objective

Patient Care

Technical Skills
The resident will be expected to master:

Technical skills of gross anatomical dissection of normal as well as abnormal surgical specimens, including sampling, fixation and special studies.

Microscopic and morphologic evaluation of tissue slides to make diagnosis of surgical pathology specimens and the interpretation of special stains.

Write and dictate concise and clear surgical pathology reports.

Organize workload so cases are processed, dictated and signed out in a timely manner.

Cut, stain and interpret frozen section biopsies.

Utilization of ancillary techniques in diagnosis.

Extraction of relevant clinical information from a patient's medical record.

Understanding of quality controland quality assurance methods in Surgical Pathology.

Clinical Consultation
The resident will learn to provide appropriate and effective consultation to clinicians and other health care providers.

The resident will participate in the management of a patient, provide advice regarding ordering of additional diagnostic tests and assisting in the interpretation of test results.
The resident will participate in clinico-pathologic conferences.

Medical Knowledge

Fund of Medical Knowledge
The resident will develop general medical and pathology knowledge relevant to the practice of pathology. This will include an understanding of basic concepts of disease; the pathophysiology of common disorders; the epidemiologic, clinical, morphologic, biochemical, and/or molecular genetic features of common disorders; the prognostic and general therapeutic implications of common disease states; and the societal impact and preventative aspects of common diseases.

Application of Medical Knowledge in the Practice of Pathology

The resident will learn to effectively apply the acquired medical knowledge in the day-to-day practice of pathology in:
Diagnosis, prognosis, differential diagnosis,and therapeutic options.

Practice-Based Learning and Improvement

Evidence-Based Practice
The resident will participate in conferences, other educational activities and private reading of pertinent pathology material to develop the skills necessary for the development and resolution of a differential diagnosis.

The resident must develop the ability to critically evaluate the quality of research studies pertinent to diagnosis and other medical decisions.

Use of Information Technology
The resident will learn to use information technologies to improve the day-to-day practice of pathology.

Interpersonal and Communication Skills

Communication Skills
The resident will learn to communicate effectively and courteously with health care providers, laboratory staff members, administrators, patients, and other individuals.
These communications will include verbal and written formats. The resident must strive to communicate in a clear, concise, accurate, and appropriately focused manner

Teamwork
The resident will learn to work as an effective member of the health care team in the course of the daily practice.

The resident must strive to perform all tasks in a responsible and timely fashion, facilitate the tasks of other team members, and be cooperative in the interactions with team members.

Professionalism

Courtesy and Collegiality
The resident must treat health care providers (including clinicians, nurses, other pathologists, technologists, transcriptionists, etc.), administrators, patients, and others courteously and respectfully

Professional Responsibility
The resident will take the professional responsibilities seriously and act accordingly.

The resident's professional responsibilities include clinical service, teaching, administrative tasks, research, institutional tasks, and work with professional organizations.

Systems-Based Practice

The Health Care System and the Role of Pathology
The resident must acquire knowledge of practice and health care delivery systems and an awareness of the role of pathology in the context of the greater health care system.

The resident will develop a working knowledge of different inpatient and outpatient delivery systems and the general regulatory and financial aspects of health care delivery.

The resident must learn the importance of providing effective and timely consultation to clinicians, advising health care providers in the provision of cost-effective care, while cognizant and in accord with patient privacy and confidentiality.

The resident should learn to provide coding, statistical and other relevant data, as needed in support of quality care and the Institution.

General Laboratory Administration
The resident will develop an understanding of the general administrative aspects of pathology practice.

The resident will learn to understand and apply the principles of quality control and quality management.

The resident will develop a working knowledge of laboratory staffing, laboratory instrumentation, workflow, turnaround time management, safety, customer service, regulatory accreditation, budget, and billing practices.

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C. Overview

The resident is instructed by staff pathologists in the principles of gross description and diagnosis. He/she performs the gross examination of all surgical specimens, and after an initial period of instruction by the staff, prepares a gross description on their own. The gross description is reviewed with the staff at the time of sign-out.

The resident examines all surgical specimens microscopically and prepares a microscopic description. The resident is also expected to formulate a diagnosis based on gross and microscopic features, as well as clinical history. At sign-out, resident and staff review the case using a double-headed microscope, the gross and microscopic descriptions are reviewed by the staff pathologist, and necessary revisions are made.

The resident is instructed in the procedures involved in rapid frozen sections and is expected to become proficient in preparing and staining frozen sections. The resident reviews microscopic features and formulates a provisional diagnosis. After review of the frozen section material with the staff pathologist, a Surgical Pathology Consultation is entered in the chart and co-signed by the resident and staff pathologist. During the third year of training, depending on individual ability, the resident may be given sole responsibility for frozen section diagnosis. Staff supervision is always available.

At the third-year level, the residents assume more independent responsibility for surgical pathology diagnosis. The third-year resident is the first to review the histology on all biopsies. After making a preliminary diagnostic decision, the third-year resident reviews critical cases with the in-house staff pathologist and communicates with the clinician who submitted the case. The third-year resident also assists and instructs junior residents in the blocking of specimens and signing out of all surgical pathology cases. The importance of using clinical information to arrive at a correct diagnosis is emphasized in our program. The third-year residents are expected to play a major role in communicating with clinical staff.

D. Service

The Surgical Pathology service is covered by two residents, a hot seat resident (or Chief Resident), and two staff members. See the tables below for delineation of responsibilities.

In- House Surgicals
Position	Duties
"In-house" resident	Rush and small biopsies, routine specimens
"In-house" staff	Frozen sections in p.m., biopsies, routine specimens
Autopsy resident	Covers frozen sections in the afternoon
"Hot seat" resident	Provisional diagnosis on all biopsies, instruction of and assistance to in-house resident.-Assists physicians from other departments and reviews cases with them.-Assist in tissue procurement

Submitted Surgicals
Resident	Frozen Sections in a.m., submitted surgical specimens
Staff	Frozen sections in a.m., submitted surgical specimens-Assist with interdepartmental conferences.

 

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E. Organization of Service

In-House Service

The resident on "in-house surgicals" and the senior staff on "in-house surgicals" are responsible for working up and rendering diagnoses on the surgical specimens.

Frozen sections

The resident and staff provide intraoperative consults to the Surgery Branch, NCI, and the Surgical Neurology Branch, NINCDS, in the operating suites located in the ACRF. Each working day until noon, the frozen sections are to be covered by the resident and staff on the submitted service, thereby freeing up the in-house resident and staff to sign out the in-house cases.

The resident is responsible for cutting, staining, and mounting the frozen section under the supervision of the staff. Touch preparations (fixed and stained with H&E, or air dried and stained with Diff Quick's stain) may provide additional diagnostic information. Check for previous material and, if pertinent, have it available at the time of the frozen section.

After a diagnosis or recommendation is made, the consult is recorded on the Consultation Form (SF 513). Complete the original and one carbon of the Consultation Form and make sure that the patient's full name and medical record number are on the form. The forms are signed by the staff and resident, and the original is filed in the patient's chart. The carbon is kept and filed with the final report. The information also should be incorporated into the final surgical pathology report. The consultation report should contain a brief description of the specimen on which the frozen section was performed and the interpretation rendered to the surgeon.

Make sure the frozen block is wrapped carefully in tissue paper (if small) put in fixative and submitted for histology. Frozen section blocks are given a specimen number followed by "FS", followed by the consecutive frozen section number for that speciemen. For example, if specimen number 5 has 2 frozen sections, the blocks would be numbered "5SF1" and "5FS2". Record the specimen number and description on the Consultation Form. The actual frozen sections are saved with the case as a permanent record.

If the frozen section shows a tumor of uncertain histogenesis, another block of tissue should be frozen for immunocytochemistry. If tissue is sparse, the block used for the frozen section should not be fixed but kept frozen for immunocytochemical staining. Additional sections may be cut immediately for immunohistochemical staining. Tissue should also be submitted in 3% glutaraldehyde for electron microscopy.

The resident is responsible for overseeing the maintenance of the equipment and the materials needed in the frozen section room. Advise the Histopathology staff of needed supplies and equipment. Indications for frozen sections:

1. Obtain a diagnosis that will dictate or modify surgical or medical therapy
2. Obtain a diagnosis that will indicate how to best handle tissue
   1. cultures
   2. special studies
   3. estrogen receptors
3. Assure that the tissue is adequate for diagnosis
4. Examine adequacy of excision "margins"
5. Provide a provisional diagnosis that will expedite additional patient care.
6. Both muscle and nerve require special handling.
   If any doubt exists to the processing of Neuropathology materials you are requested (required) to call the neuropathologist before anything is done. - See neuropathology section (above) for specific instructions.

Location and Maintenance of the Frozen Section Room

The frozen section room is currently located adjacent to the operating room suites (2C533). There are two cryostats: either or both may be used. There is also a cryostat and stain set-up in both the autopsy room and the histology room. These areas are maintained and supervised by Histopathology staff and any questions regarding necessary supplies should be directed to them.

It is the responsibility of the resident on surgicals to ensure that the machine should be cutting properly, the stains are fresh and working, and the microscope is in good working order. The frozen section room should be checked at either the beginning or end of each week so that proper frozen sections are prepared during the week. Any problems should be communicated to the Histology Laboratory promptly.

WHEN THE TISSUE IS FRESH, THINK:

• Tissue for microbiology
• Proper fixative, like Orth's for chromaffin reaction
• Tissue for EM, other morphological studies; immunologic studies, etc.
• Tissue for viral isolations, tissue culture, etc.
• Deep freeze for "biochemical determination," etc.

Division of Specimens

A large number of specimens are divided immediately after surgery so that portions of tissue can be used by different research programs. As a rule, specimens are divided in the blocking room (2A22) and a resident (and "hot seat" or staff) should respond to the call as soon as it is received. A tissue procurement nurse in charge of distributing the specimen will transport it from the OR and take charge of the distribution.

MAKE SURE THERE IS ENOUGH TISSUE TO ESTABLISH THE DIAGNOSIS AND EVALUATE THE SPECIMEN (e.g., DO NOT GIVE AWAY MARGINS). REFER TO MANUAL OF INSTRUCTIONS FOR BLOCKING TECHNIQUES OF VARIOUS SPECIMENS. IN CASE OF DOUBT ASK FOR HELP.

Intake of Specimens

The specimens that are in the laboratory are grossed as soon as possible during the day with the assistance of one histology technician. The resident should go over the specimens and decide which are "small biopsies" and "large biopsies" and which are "routines." The classification of each specimen should be indicated on the blocking log sheet.

"Small biopsies" that are fixed are processed overnight and ready next day by noon or 1:00p.m. The "large biopsies" are fixed for 24 hours before processing. Provisional diagnoses are made by the "hot seat" fellow. If the biopsy is received in saline, discard the fluid before adding formalin, otherwise the biopsies will not be fixed properly.

"Routines" are handled with second priority. See the GROSS ROOM PROCEDURES. Remember a diagnosis cannot be made unless the tissue is ADEQUATELY FIXED. A 24-HOUR WAIT IS LESS TRAUMATIC TO THE PATIENT, THE SURGEON, AND THE PATHOLOGIST THAN IS A SECOND BIOPSY.

If finished blocking before 3:00p.m., the resident should "sweep" the laboratory for other biopsies and specimens. Gross specimens should be photographed.
Dictation completed by 4:00p.m. will be transcribed the same day.

Surgical Specimens Requiring Decalcification

A bone biopsy in which the bone itself represents part of the diagnostic material will not be signed out until all decal sections are processed. Regardless of the findings in soft tissue, the case will be held until the decal specimens are processed. Only those cases in which the bone specimen is an incidental procedure not of diagnostic relevance will be signed out without decal specimens. For example, a thoracotomy specimen, which includes a rib removed incidentally as part of the procedure, may be signed out prior to processing of the rib biopsy if the rib showed no gross pathologic abnormality. Ribs are examined grossly only unless otherwise specified.

After decalcification, residents will block all surgical specimens and submit them for histologic sections. Surgical specimens will not be blocked by the Histopathology Laboratory staff under any circumstances.

A log will be maintained in the surgical pathology blocking room to follow all surgical specimens requiring decalcification. Bone specimens undergoing decalcification will be checked on a daily basis, and decal solutions will be changed on a daily basis. The log will also contain the following information:

• The date the specimen went into decalcification
• The surgical pathology number
• The name of the resident
• The diagnosis
• Type of decalcification solution being used
• The date the specimen is finally processed for histologic examination

Routine decal solution (formic acid) and other rapid decal solutions destroy enzymatic activity, particularly chloro-acetate esterase reactivity in neutrophils and mast cells. When enzymatic activity is of importance in evaluating a specimen, alternative decal solutions should be used. EDTA is currently available and will preserve enzymatic activity. Touch preps may also be prepared from bone biopsies, and these are often suitable for cytochemical reactions.

Work-up of the Case and Sign-out

• ALWAYS CHECK TO SEE IF THE PATIENT HAS PREVIOUS MATERIAL RELEVANT TO THE CURRENT BIOPSY IN OUR FILES-IF SO, PULL IT OUT AND REVIEW IT.
• The cases are checked out with the staff the next morning at 8:30a.m. Have the case ready with a written, short microscopic description, a diagnosis, and previous slides (if applicable).
• ALWAYS COMMIT YOURSELF; DO THE BEST YOU CAN. Read about your cases before coming to sign-out.
• The diagnostic line should read:
  • Organ or tissue, site (procedure): pathological diagnosis; e.g., Skin, left forearm, (excisional biopsy): basal cell carcinoma (margins positive)
  • Thyroid, (total thyroidectomy): adenoma
  • Soft tissue, left thigh (biopsy): diagnosis deferred (see micro)
• After checkout with the staff, dictate the final report using the telephone-based dictation system (4-2828).
• If your interpretation differs from that of "hot seat" fellow, the case must be discussed with him/her and if necessary additional staff consultations sought.

Screening for Surgical Case Review Committee

Cases may be considered for possible referral to the Surgical Case Review Committee, based on criteria (see Appendix A9) requiring referral. If a case meets a criterion for committee review, alert Dr. Armando Filie and complete a referral form.

Dictation Guidelines for Transcription

GROSS-Dictation of gross reports is to be done on the hands-free Lanier unit located in the specimen room near the OR. Depress ON/OFF button, enter assigned dictation number, and give needed information in the following order:

• Surgical Pathology Number
• Patient name (please spell if unusual).
• It is not necessary to dictate the clinical diagnoses, patient history, etc., as this information is already entered in the system and will automatically appear at the top of the report.
• Cut-off time is 4:00p.m.-Dictation completed up to this time will be transcribed the same day. If you wish to continue dictating, simply turn the recorder off and then back on and re-enter your dictation number.

MICROSCOPIC - Dictation of microscopic reports is to be done using telephone call-in dictation lines (Speed Dial 4-2828). Dial recorder number, enter assigned dictation number, and report type. Use 3 to reverse, 1 to listen, 4 to pause, and 2 to resume dictation. When finished with dictation, press 9 and hang up the telephone. These numbers can be accessed at any time, as often as needed-phones should not be left unattended, as recorders are voice activated. If changes are needed in gross, they should be indicated at the time of microscopic dictation.

When dictating microscopic reports, give needed information in the following order:

1. Surgical Pathology Number
2. Patient name (please spell if unusual)
3. Diagnoses
4. Note
5. If changes to, or continuation of gross is needed, please indicate such at this time
6. Staff physician and resident
7. Distribution. Indicate here if a telephone diagnosis was transmitted, to whom, by whom, and the date and time. Indicate if slides or blocks are being returned, and to whom

If you need to speak directly with the transcription office, you may reach them at 496-1838. You may call if you are having problems with the equipment or need to discuss a dictation.

Appendix C8 contains a reprint that discusses standards for the surgical pathology report. Please read these standards carefully and ensure that your reports meet them. Pay particular attention to the sections pertaining to gross and microscopic descriptions, and the final diagnosis.

Signing Reports

The transcriptionists complete reports within 4 hours. Before the reports are verified and released, the reports need to be carefully proofed and signed by the resident and the staff. The resident should edit the reports using the Soft Path™ LIS system before giving the reports to the staff for approval of signatures. MAKE SURE YOU SIGN THE REPORTS BEFORE 3:00 P.M., AND THAT THEY ARE ACCURATE.

Reports Erroneously Issued Under an Incorrect Name or Requisition

-----The following procedures are required if a pathology report is inadvertently issued under an incorrect name:

• Issue a new report under the correct name and hospital identification number
• Issue a revised report under the "incorrect name" that was used to generate the original report. In that supplemental report, state the sequence of events as they transpired. If no clinical action was taken based on the incorrect report, that should be clearly stated. For example, "no clinical action was taken based on the incorrect report and, therefore, there was no adverse clinical consequence of the incorrect report." State how the error took place. Physician initiated requisition under incorrect name, or requisition entered erroneously in pathology. Do not redictate the incorrect diagnosis
• Hand-carry the new correct report plus the revised report to Jerry King in Medical Records. They will pull the incorrect report from patient's chart and replace it with the supplemental report documenting what took place.

Supplemental and Revised Reports

Both have different advantages and disadvantages, and should be used in different circumstances.

The Supplemental may be used to provide additional information that does not change the original diagnosis. The supplemental also can be used to add a brief comment to a previously verified report; e.g., special stains for organisms are negative.

If you wish to change or add a diagnosis, this should be done only in the form of a Revised Report.

The Supplemental or Revised report should be distributed to all individuals who received the original report.

In issuing a Revised report, the previous incorrect information (diagnosis, patient name, accession number, etc.) should be explicitly stated in the body of the report.
Reasons for change in interpretation should be provided if relevant; e.g. additional clinical data, outside consultation, additional immunophenotypic or molecular data.
The corrected diagnosis as well as all other diagnosis, even if unchanged. The revised report replaces the original report in the SoftPath computer system.
If the corrected diagnosis would result in a change in clinical management, the information should be reported verbally to a responsible physician, and documented in the report under "Distribution".

The Revised reports and Supplemental reports will be filed with all previous reports.

Fixation and Handling of Surgical Specimens After Regular Working Hours

Specimens from the nursing units or clinics obtained after working hours at night or on weekends will be delivered to the receiving area outside the Histology Laboratory (2A22).

Those specimens should be delivered in fixative.

In order to ensure optimal preservation and fixation of those surgical specimens that are obtained after regular working hours, we suggest that, in all such cases, the OR contact the pathology resident on call (through paging, 496-1211) and provide the resident with basic information about the case (diagnosis, type of surgery). This will enable the resident to begin to make an informed decision about how to best handle the tissue.

Final decisions may require discussion with the clinician and/or review of previous pathologic material. Possible options include the following:

• Routine fixation in formalin. In this case, small specimens can be placed directly in a container containing 10% buffered formalin. We will make sure that formalin is readily available to the OR staff. It should be noted that large specimens may need to be examined by the pathologist prior to such fixation. Specimens must not be squeezed into too-small containers!
• Selection of tissue for electron microscopy. This is necessary in cases of small round cell tumor, brain biopsy, pituitary adenoma, and in instances in which the diagnosis (particularly of malignancy) is not firmly established.
• Preparation of a frozen (OCT) block. For hematopoietic lesions, small round cell tumors, and occasionally in other situations.
• Fixation in B5. B5 fixation is no longer used because it contains mercury, an environmental hazard. B5 fixation interferes with PCR.
• Preparation of tissue imprints (touch preps). Useful for hematopoietic lesions, infectious lesions, and neoplasms in general.

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"Hot Seat" Service

• The hot seat fellow reviews all biopsies as soon as they become available.
  After review he/she will make a diagnosis and will take all the calls in reference to the biopsies. Calls will be referred to the hot seat person until the biopsy is signed out. If the hot seat fellow has spoken to a clinician, a "pathology alert" label should be placed on the tissue examination form, and the diagnostic information communicated written on the form.
• The fellow will, when indicated, order levels and special stains. A note of any orders put through the Histology Lab should be written on the front sheet of the tissue examination form.
• After the fellow has reviewed the biopsies he/she will give the slides and forms to the resident on the In-house surgical pathology service.
• The hot seat fellow will maintain a Case Log recording: 1) Name & case No. reviewed; 2) preliminary diagnosis; 3) persons to whom the diagnosis was reported; and 4) final diagnosis. If the "hot seat" resident transfers coverage to another "hot seat", the Case Log will be handed over to the alternate resident.
• The In-house resident must inform the hot-seat resident immediately if there is a change in the diagnosis at sign out with the staff, and communicate any changes in diagnosis to clinicians that were previously contacted.
• LP senior staff will be available for consultations throughout regular working hours.
• The hot seat resident will also be responsible for offering instruction and assistance to junior residents regarding blocking and division of specimens. For residents beginning their first rotation on in-house surgicals, the hot seat resident will be available on a continuous basis to instruct the resident regarding principles of blocking and gross description. After appropriate orientation has taken place (approx. 1-2 weeks) the hot seat resident will be available to the junior resident as needed for handling of difficult or complicated specimens. The hot seat resident will also be available to junior residents after hours as required.
• The hot seat resident will assist in the instruction of new residents in the performance of autopsies, assisting with prosection.
• The hot seat resident will review cases with clinicians who wish to review slides on their patients.
• The hot seat resident is responsible for all tissue procurements. He/she performs or oversees tissue distribution to insure that adequate material is retained for diagnosis.
• The hot seat resident should record all tissue distributions so that this information can be recorded in the pathology report.
• The hot seat resident covers frozen sections in the afternoon, (or arranges other coverage) should the resident on autopsie service be unavailable.

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Submitted Surgicals

CHECKLIST FOR RESIDENT ON SUBMITTED SURGICAL PATHOLOGY:

• Check demographic information
  • Are name, age, and sex correct?
  • Compare with both tissue exam sheet and outside reports
  • If patient is registered as an NIH patient, is NIH unit number shown?
  • Check both Tissue Exam sheet and CRIS system for NIH#
• GROSS DESCRIPTION
  • Describe in detail number of slides and blocks received, including their identity.
  • If slides/blocks came from more than one hospital, make sure all institutions are listed, including their addresses (city/state)
• DIAGNOSIS
  • Must include outside S# for each specimen received.
• DISTRIBUTION
• Should specify individuals to receive reports, including submitting physician and outside pathologists.
• List here all blocks/slides being returned.
• We retain the H&E stained sections on all cases. This policy is standard practice for all interdepartmental consultations and patient referrals. If a question is raised, you may refer the individual to the policy statement of ADASP: Consultations in Surgical Pathology; Am J Surg Pathol 17: 743-745, 1993. In general, we will return submitted blocks and special stains. Some research protocols require that we retain paraffin blocks for special studies (e.g., lymphomas, pediatric tumors, breast cancers). Requests to retain blocks should be handled by the staff pathologist responsible for the protocol.

• Indicate for secretary which form letter is to be sent, e.g., A, B, C. For C letter, specify what material is being returned.
• A diagnosis should be listed for every specimen received, even if it is "forwarded to hematology" or "forwarded to cytology."
• Cases are never deaccessioned. Once it is logged in, a report must be issued. You may state that case was forwarded to another hospital without review, but the report must contain a diagnostic line, or the case will be incomplete, i.e., no card file entry.
• If you receive duplicate material on a case that is signed out under another S#, issue a report referring to that NIH S# in the diagnostic line.

Additional material (stained slides, blocks) received before the case has been signed out should be given to Surgical Pathology office staff. List patient's name and current NIH S#.

Additional material received after the case is signed out, but from the same specimen (not a new biopsy on same patient), should be logged in with a request for a supplemental report. Use same S # as original case, and forward to histology.
If you receive multiple blocks (> 5), you should try to select particular blocks to be recut for special stains, etc., after consultation with staff.

Once the additional material has been accessioned, you may enter a request for special studies in the SoftPath LIS.

Proof report carefully before signing it.

The resident on "submitted" surgicals is responsible for working up all the referred cases with the staff member on submitted service.

The material accessioned in the laboratory should include a complete tissue examination form filled out by the NIH clinician. It is essential that an accompanying pathology report or other document verifying that the slides submitted belong to the patient in question be available. In addition, the material may include slides, blocks, and wet tissue. When blocks are received, it is customary to prepare our own slides. Make sure that the outside code on the slide label is also on the NIH label.

As soon as you get the case from the Histology Laboratory, do a workup and decide if more sections are needed or if you have to request the blocks from the referring hospital. When you receive blocks you have requested, submit it as additional material (see above).

Check and work up the cases with the staff on the submitted service. Finish the report in the same fashion you would for an in-house surgical and give it to the secretary (see under In-House Service, #4 and #5). Include in the GROSS description the identity of all submitted slides and blocks, including the outside hospital, as well as the date of the original procedures (which may be different from the report date). With the staff, prepare the form letter to go to the referring pathologist, and identify any slides (special stains) or blocks to be returned.

Our policy is to retain submitted slides in any case in which we render a diagnosis. If we have prepared our own slides from the paraffin blocks, we may then return submitted slides, if they do not demonstrate significantly different pathologic findings, and only if they have been requested by the outside laboratory. Requests for return of submitted slides in cases in which we do not have other material must be cleared with the senior staff. Such requests will usually not be honored if the patient is or has been treated at the Clinical Center. In addition, we try to retain a paraffin block in many instances for further studies.

The resident on submitted service covers frozen section consultations until noon.
NCI protocol guidelines require that we document, to the extent possible, the date of diagnostic biopsies. For submitted surgical specimens, this information should be included in the GROSS DESCRIPTION portion of the pathology report, and should be dictated by the resident.

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