Sirt1 Protects Stressed Adult Hematopoietic Stem Cells
The immune system relies on a stable pool of hematopoietic stem and progenitor cells (HSPCs) to respond properly to injury or stress. Read more about how Sirt1 protect stressed adult hematopoietic stem cells...
Posted: 05/2013
Lipid Biomarkers Identified for Liver Cancer
Hepatocellular carcinoma (HCC) is an aggressive cancer of the liver with poor prognosis and growing incidence in developed countries. Learn more about lipid biomarkers identified for liver cancer…
Posted: 5/2013
CD47: A Master Regulator of Stemness
The thrombospondin-1 receptor CD47 seems to limit cell survival and regeneration after stress. Learn more about CD47…
Posted: 4/2013
FBXW7 protein has dual-role as tumor suppressor and inflammatory pathway inhibitor
Toll-like receptors (TLRs) are largely responsible for inducing innate immune responses to infection. Learn more about FBXW7 protein's dual-role as a tumor suppressor and inflammatory pathway inhibitor…
Posted: 04/2013
A Novel Model for Squamous Cell Carcinoma of the Lung
In the U.S. lung cancer remains the most deadly cancer type with less than one in five patients alive five years after diagnosis. Learn more about squamous cell carcinoma of the lung...
Posted: 4/2013
Novel approach using DNA-RNA hybrids in RNA nanotechnology
Developing simple approaches to detect interactions, modifications, and cellular locations of macromolecules is essential for understanding biochemical processes. Learn more about the use of DNA-RNA hybrids in RNA nanotechnology…
Posted: 4/2013
Stromal loss of TGFβ drives cancer growth in the epithelium via inflammation
Interactions between epithelial and stromal cells play an important role in cancer development and progression. Learn more about how stromal loss of TGFβ can affect cancer growth…
Posted:3/2013
Novel Antibody Targets Glypican-3 in Liver Cancer
New treatments for patients with liver cancer, the third most common cause of cancer-related death, are desperately needed. Learn more about the antibody target glypican-3 …
Posted: 3/2013
Englerin A Delivers One-Two Punch to Kidney Cancer Cells
John Beutler, Ph.D., and his colleagues, in CCR’s Molecular Targets Laboratory located at the NCI campus in Frederick, Maryland, identified englerin A from an extract of the African plant Phyllanthus engleri that was particularly toxic to kidney cancer cells. Learn more about the activity of englerin…
Posted: 3/2013
The Role of Dimerization in Raf Signaling
Of the proteins in the cascade, Rafs have the most complex regulatory mechanisms, including the ability to form dimers. Learn more about the role of dimerization in Raf signaling…
Posted: 02/2013
A Role for Small Antibody Fragments to Bind and Neutralize HIV
Env an attractive target for designing therapeutic inhibitory antibodies. Learn more about how small antibody fragments can bind and neutralize HIV…
Posted: 02/2013
Sunitinib Proves Beneficial in Metastatic Kidney Cancer
Many researchers and clinicians consider targeted therapies, such as tyrosine kinase inhibitors and antibody-based drugs, to be a great advance in the treatment of patients with cancer.…Learn how sunitinib is beneficial for treating kidney cancer
Posted: 2/2013
CD22: A Promising Target for Acute Lymphoblastic Leukemia Treatment
There are about 4,000 new cases of acute lymphoblastic leukemia (ALL) in the United States each year. Learn more about acute lymphoblastic leukemia treatment…
Posted: 2/2013
Newly-Identified Fragile Sites Push Stressed Cells toward Cancer
Understanding how the changes in genomes of cancer cell arise can give researchers new insights into the process of cancer development. Learn more about the chromosomal alterations of cancer cells…
Posted: 01/2013
