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New Method for Producing Significant Amounts of RNA Labeled at Specific Sites

Among biomacromolecules, RNA is the most versatile, and it plays indispensable roles in almost all aspects of biology. Learn more about the new method for producing significant amounts of RNA labeled at specific sites…

Mutant HABP2 Causes Non-Medullary Thyroid Cancer

Cancer of the thyroid is the most common endocrine cancer and the eighth most common cancer in the U.S. Learn more about how mutant HABP2 causes non-medullary thyroid cancer…

Paradigm Shift in Thyroid Hormone Mechanism of Action

Thyroid hormone (TH) is one of the primary endocrine regulators of human metabolism and homeostasis. Learn more about the paradigm shift in thyroid hormone mechanisms of action…

Changes in Bacteria Induce Inflammatory Skin Diseases

Atopic dermatitis (AD) is a chronic inflammatory skin disease that manifests as dry skin with a relentless itch and eczema. Learn more about how changes in bacteria induce inflammatory skin diseases…

Synthetic Spores Give Insight into the Real Thing and Reveal Functional Applications

Spores from bacteria, such as Bacillus subtilis, are produced to allow the bacterium’s genetic material to survive harsh environments. Learn more about synthetic spores give insight into the real thing and reveal functional applications…

Splicing Modulation as a Potential Treatment for Vemurafenib-Resistant Melanoma

Vemurafenib is a potent kinase inhibitor with remarkable clinical activity in BRAF(V600E)-positive melanoma tumors. One known resistance mechanism is aberrant splicing of the BRAF RNA. Learn how splicing of the BRAF RNA is used as a potential treatmenat for vemurafenib-resistant melanoma…

Hepatic Stellate Cells Alter Liver Immune Environment to Promote Cancer

Hepatocellular carcinoma (HCC) is the most common form of liver cancer, accounting for up to 90 percent of cases, and is the second most common cause of cancer-related deaths worldwide according to the World Health Organization’s 2014 World Cancer Report. Learn more about how activated hepatic stellate cells alter the liver microenvironment to promote the recurrence of cancer…

Adoptive T-cell Therapy Promising for Metastatic Cervical Cancer

Over 4,000 women in the U.S. die from cervical cancer each year. Learn why adoptive T-cell therapy is promising for metastatic cervical cancer…

Stop Stalling: Mus81 Required for Efficient Replication

DNA replication is precisely controlled to ensure that daughter cells receive intact, accurate genetic information. Learn why Mus81 is required for efficient replication…

Mig6 Puts the Brakes on Mutant EGFR-Driven Lung Cancer

Lung cancer is the most common cause of cancer-related death worldwide. These cancers are often induced by mutations in the epidermal growth factor receptor (EGFR), resulting in constitutive activation of the protein’s tyrosine kinase domain. Learn how Mig6 puts the brakes on mutant EGFR-driven lung cancer…

Immunotoxin Targeting Glypican-3 Effective against Liver Tumors

Worldwide, liver cancer is the fifth most common malignancy, and hepatocellular carcinoma (HCC) makes up about two-thirds of those cases. Learn more about how immunotoxin targeting glypican-3 can be effective against liver tumors…

Identifying a New Mechanism of HIV Core Formation

During the maturation of human immunodeficiency virus 1 (HIV-1), viral particles transition from a noninfectious form to an infectious one, and this conversion requires the cleavage of the HIV-1 Gag polyprotein. Learn more about how to identify new mechanisms of HIV core formation…

p53 Regulates Bone Differentiation and Osteosarcoma Formation

Osteosarcoma is an uncommon cancer that usually begins in the large bones of the arm or leg, but is the second leading cause of cancer-related death in children and young adults. Learn how p53 regulates bone differentiation and osteosarcoma formation…

Small RNA Enhances Antitumor T-cell Therapy

Adoptive T-cell transfer is an effective form of anticancer immunotherapy in which patients receive infusions of cytotoxic T cells that seek out and destroy targeted cancer cells. Learn more about how small RNA enhances antitumor t-cell therapy…

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CCR In The Journals Archive