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Large Population-Based Study Reveals Disparities in Myeloma Precursor Disease

African Americans are more than twice as likely as whites to develop Mutiple Myeloma (MM), but the reason for this higher prevalence is not entirely clear. Learn more about how large population-based studies reveal disparities in myeloma precursor disease…

Small Molecule Disrupts Abnormal Gene Fusion Associated with Leukemia

Rare chromosomal abnormalities, called chromosomal translocations, in which part of a chromosome breaks off and becomes attached to another chromosome, can result in the generation of chimeric proteins. Learn how small molecule disrupts abnormal gene fusion associated with leukemia…

Changes in miRNAs Signal High-Risk HPV Infections

Numerous studies have shown that the levels of cellular miRNAs can be altered in diseased tissues, and these changes potentially could be used for diagnosis or disease monitoring. Learn more about how changes in miRNAs signal high-risk HPV infections…

Ionizing Radiation Enhances Monoclonal Antibody Effectiveness through Increased Target Expression

A type of targeted therapy, mAbs function by binding specific surface-expressed proteins and directly inhibiting their activity, often preventing cell proliferation, or inducing a cell-killing immune response called antibody-dependent cell-mediated cytotoxicity (ADCC). Learn more about how ionizing radiation enhances monoclonal antibody effectiveness through increased target expression…

Global Gene Expression Profiles Identify Metastasis Regulatory Networks

Metastasis is a systemic disease in which cancer cells break away from a tumor and migrate to other parts of the body, usually via the blood or lymphatic systems, to form new tumors. Learn more about how global gene expression profiles identify metastasis regulatory retworks…

Flipping the NF-κB Switch in Macrophages

A critical component of the innate immune system, macrophages respond to diverse microbes by recognizing certain molecular patterns, such as the Gram-negative bacteria product lipopolysaccharide (LPS), via Toll-like receptors. Read more about flipping the NF-κB switch in macrophages…

Cell Line Panel Reveals Repair Pathways Important to DNA Damaging Drugs

DNA topoisomerases I and II (Top1 and Top2) facilitate DNA replication by relaxing supercoiled DNA but use distinct mechanisms. Learn more about how cell line panels reveal repair pathways important to DNA damaging drugs…

Wnt Inactivation for Liver Cancer Therapy

One potential avenue of research in HCC treatment has been the Wnt signaling pathway. Learn how wnt inactivation can provide a potential therapy for liver cancer…

Radiation-Induced Immunogenic Modulation Enhances T-Cell Killing

For many types of cancer, including breast, lung, and prostate carcinomas, radiation therapy is the standard of care. Learn more about how radiation-induced immunogenic modulation enhances t-cell killing…

TNF-induced necroptosis requires the plasma membrane localization of the MLKL protein

The mixed lineage kinase domain-like protein (MLKL) has been identified as a key downstream component of TNF-induced necroptosis in human colon adenocacinoma cultured cell lines (HT29 cells). Learn more about TNF-induced necroptosis…

Genome-wide overlap in the binding location and function of chromatin-remodeling proteins

For DNA to become accessible local chromatin regions need to be “opened” up. This process is called chromatin remodeling. Learn more about chromatin-remodeling proteins…

Immune Suppression Enhances Effectiveness of Mesothelioma Targeted Immunotoxin

Malignant mesothelioma is an aggressive cancer of the linings of the organs in the chest and the abdomen and is often caused by exposure to asbestos. Learn more about how immune suppression enhances effectiveness of mesothelioma targeted immunotoxin…

Repair Mechanism of UV-damaged DNA in
Xeroderma Pigmentosum

Xeroderma pigmentosum (XP) is a rare, inherited disorder characterized by extreme skin sensitivity to ultraviolet (UV) rays from sunlight. Learn more about a repair mechanism of uv-damaged DNA…

HIV envelope glycoprotein imaged at high resolution

The outer surface of the human immunodeficiency virus (HIV) is surrounded by an envelope studded with spike-shaped glycoproteins called Env that help the deadly virus identify, bind, and infect cells. Learn more about how glycoproteins help HIV identify, bind, and infect cells…

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CCR In The Journals Archive