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Hepatic Stellate Cells Alter Liver Immune Environment to Promote Cancer

Hepatocellular carcinoma (HCC) is the most common form of liver cancer, accounting for up to 90 percent of cases, and is the second most common cause of cancer-related deaths worldwide according to the World Health Organization’s 2014 World Cancer Report. Learn more about how activated hepatic stellate cells alter the liver microenvironment to promote the recurrence of cancer…

Adoptive T-cell Therapy Promising for Metastatic Cervical Cancer

Over 4,000 women in the U.S. die from cervical cancer each year. Learn why adoptive T-cell therapy is promising for metastatic cervical cancer…

Stop Stalling: Mus81 Required for Efficient Replication

DNA replication is precisely controlled to ensure that daughter cells receive intact, accurate genetic information. Learn why Mus81 is required for efficient replication…

Mig6 Puts the Brakes on Mutant EGFR-Driven Lung Cancer

Lung cancer is the most common cause of cancer-related death worldwide. These cancers are often induced by mutations in the epidermal growth factor receptor (EGFR), resulting in constitutive activation of the protein’s tyrosine kinase domain. Learn how Mig6 puts the brakes on mutant EGFR-driven lung cancer…

Immunotoxin Targeting Glypican-3 Effective against Liver Tumors

Worldwide, liver cancer is the fifth most common malignancy, and hepatocellular carcinoma (HCC) makes up about two-thirds of those cases. Learn more about how immunotoxin targeting glypican-3 can be effective against liver tumors…

Identifying a New Mechanism of HIV Core Formation

During the maturation of human immunodeficiency virus 1 (HIV-1), viral particles transition from a noninfectious form to an infectious one, and this conversion requires the cleavage of the HIV-1 Gag polyprotein. Learn more about how to identify new mechanisms of HIV core formation…

p53 Regulates Bone Differentiation and Osteosarcoma Formation

Osteosarcoma is an uncommon cancer that usually begins in the large bones of the arm or leg, but is the second leading cause of cancer-related death in children and young adults. Learn how p53 regulates bone differentiation and osteosarcoma formation…

Small RNA Enhances Antitumor T-cell Therapy

Adoptive T-cell transfer is an effective form of anticancer immunotherapy in which patients receive infusions of cytotoxic T cells that seek out and destroy targeted cancer cells. Learn more about how small RNA enhances antitumor t-cell therapy…

First-in-Human Study of Interleukin-15 as Immunotherapy for
Metastatic Cancer

One of the hallmarks of cancer that is now more clearly recognized is tumors’ ability to avoid recognition and destruction by the immune system. Learn more about the first-in-human study of interleukin-15 as immunotherapy for metastatic cancer…

Drosophila TDP1 Ortholog Important for Longevity and Nervous System Maintenance

As the molecule responsible for encoding a cell’s hereditary information, DNA must maintain its integrity. Learn more about the importance of drosophila TDP1 ortholog for longevity and nervous system maintenance…

CAR T Cell Immunotherapy Promising in Refractory Leukemia

Therapies that harness the power of the immune system are a more recent addition to the anticancer arsenal. Learn more about CAR T cell therapy, which genetically reprograms a patient’s own T cells to express a chimeric antigen receptor…

Designing and Testing Functional RNA Nanoparticles

Recent advances in nanotechnology have generated excitement that nanomaterials may provide novel approaches for the diagnosis and treatment of deadly diseases, such as cancer. Learn more about designing and testing functional RNA nanoparticles…

Finding Order in Randomness: Single-Molecule Studies Reveal Stochastic RNA Processing

Producing a functional eukaryotic messenger RNA (mRNA) requires the coordinated activity of several large protein complexes to initiate transcription, elongate nascent transcripts, splice together exons, and cleave and polyadenylate the 3’ end. Learn more about how single-molecule studies reveal stochastic RNA processing…

Tumor-Protective Mechanism Identified from Premature Aging Disease

Patients with Hutchinson-Gilford Progeria Syndrome (HGPS) do not develop another aging-related disease, cancer, despite having dramatically elevated levels of DNA damage. Learn more about the tumor-protective mechanism identified from premature aging disease…

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CCR In The Journals Archive