Gene Signature Improves Prediction of MDR Ovarian Cancer Survival
CCR scientists found an 11-gene signature that improves prediction of overall survival of ovarian cancer patients whose disease becomes resistant to standard chemotherapy drugs. Learn more about how gene signatures improve ovarian cancer survival…
Posted: 5/2012
Lapatinib Shows Success Against Cholangiocarcinoma
Findings from recent genomic characterization of CCA show that lapatinib could successfully target a type of CCA that is resistant to standard treatment. Learn more about lapatinib…
Posted: 4/2012
Variants of MBL2 Gene Associated with Colon Cancer Risk in African Americans
Evidence from a case-control study suggests that certain genetic alterations of a protein that inhibits inflammation are associated with increased susceptibility to colon cancer in African Americans. Learn more about MBL2…
Posted: 04/2012
Gene Loss Associated with Poor Pancreatic Cancer Prognosis
A recurrent alteration in the copy number of a group of genes, including the deletion of a gene known as CPGL, is associated with shorter survival times in some pancreatic cancer patients. Read more about
gene loss...
Posted: 03/2012
p53, a New Master Regulator of Stem Cell Differentiation
When the genome is damaged, a key player in stabilizing and maintaining genomic integrity is a protein called p53. Learn more about p53...
Posted: 03/2012
TEM8 May Be a Better Anti-Angiogenesis Target
Dr. Brad St. Croix and his colleagues demonstrated that a host-derived vascular signaling molecule called TEM8 is a new and improved target for blocking tumor angiogenesis. Learn more about TEM8...
Posted: 2/2012
Th17 Immune Cells in vivo: Friend or Foe?
Upon encountering an antigen, T cells bearing CD4+ (a helper marker) proliferate and become polarized. Learn more about Th17 immune cells...
Posted: 12/2011
Mapping Cancer Cells’
Starting Lines
Many of the defective regulatory pathways that lead to aberrant proliferation in cancer converge on DNA replication. Learn more about replication start sites...
Posted: 11/2011
Targeted Infrared Photoimmunotherapy
for Cancer
A longstanding goal of cancer therapy is the extensive destruction of cancer cells with minimal collateral damage to normal cells. Learn more about targeted photoimmunotherapy...
Posted: 10/2011
From SHAPE Signatures to
3-D Structures
RNAs undergo extensive folding to form sophisticated based-paired secondary structures that are, in part, indicators of more complex three-dimensional structures. Learn more about SHAPE Signatures...
Posted:10/2011
For Nicotine, Dose Matters
Nicotine replacement therapy (NRT) is frequently part of a person’s regimen for smoking cessation. Learn more about nicotine replacement therapy...
Posted: 10/2011
New Technique Identifies First Events in Translocations
A novel technique that enables scientists to measure and document tumor-inducing changes in genomic DNA is providing new insight into the earliest events involved in the formation of leukemias, lymphomas and sarcomas. Learn more about this novel technique...
Posted: 10/2011
Recombination Origin of Retrovirus XMRV
Xenotropic murine leukemia virus–related virus (XMRV) was first reported in samples from a human prostate tumor in 2006. Learn more about the retrovirus XMRV...
Posted: 10/2011
Stem-Like Memory T Cells
Are Discovered
T cells are the white blood cells that are the body’s first line of attack against foreign invaders. Learn more about how stem-like memory T cells are discovered...
Posted: 9/2011
