NCI Logo
NCI Logo

Understanding Papillary Renal Cell Carcinoma

Renal cell carcinoma (RCC), the most common form of kidney cancer in adults, is not a single disease but rather a collection of different tumor types driven by distinct genetic changes that arise within the same tissue. Learn more about the importance of understanding papillary renal cell carcinoma…

Insight into Prostate Cancer Stem Cells

The majority of prostate cancers display a luminal phenotype, but little is known about the stem/progenitor properties of transformed prostate cells. Learn more about the insight into prostate cancer stem cells…

Naïve-Derived T Cell Adoptive Immunotherapy is Impaired by Memory T Cells

ACT in mice using cells derived from naïve T cells (TN) have superior antitumor activity compared to similar numbers of cells from memory T cells. Learn why naïve-derived T cell adoptive immunotherapy is impaired by memory T cells…

Identifying Stem-like Cells Using Mitochondrial Membrane Potential

Long-term engraftment of cells – for months or years – and the generation of large numbers of progeny are characteristics of stem cells. Learn how to indentify stem-like cells using mitochondrial membrane potential…

Noncoding RNA Shows Context-Dependent Function

In addition to well-studied protein coding sequences, it is known that the genomes of higher organisms produce numerous noncoding RNAs (ncRNAs). Learn how noncoding RNA shows context-dependent function…

T Cells that Recognize HPV Protein Can Target Virus-Infected Cells

Treating patients with T cells isolated from a tumor and subsequently expanded in the lab can cause the complete regression of some melanomas and cervical cancers, but the treatment is currently restricted to a few cancer types. Learn how T cells that recognize HPV protein can target virus-infected cells…

Pancreatic Cancer Sensitive to Selective p38 Pathway Inhibition

Pancreatic ductal adenocarcinoma (PDAC), the most-common cancer of the pancreas, is an aggressive disease that is estimated by the American Cancer Society to be the fourth leading cause of cancer death in men and women in 2015. Learn more about the role of selective p38 pathways in pancreatic cancer…

Mutations Allow JC Polyomaviruses to Elude Antibody Recognition

JC polyomavirus (JCV) infects the urinary tract of most adults. In healthy individuals, JCV infection does not cause noticeable symptoms. Learn more about how mutations allow JC polyomaviruses to elude antibody recognitionn…

Mitochondrial DNA Unwinding Enzyme Required for Liver Regeneration

The liver has an exceptional capacity to proliferate. This ability allows the liver to regenerate its mass after partial surgical removal or injury and is the key to successful partial liver transplants. Learn why mitochondrial DNA unwinding enzyme is required for liver regeneration…

Regulatory RNA Key Player in p53-Mediated Apoptosis in Embryonic Stem Cells

Embryonic stem cells (ESCs) must maintain the integrity of their genomes or risk passing potentially deleterious mutations on to numerous tissues. Learn more about why regulatory RNA is a key player in p53-mediated apoptosis in embryonic stem cells…

New Method for Producing Significant Amounts of RNA Labeled at Specific Sites

Among biomacromolecules, RNA is the most versatile, and it plays indispensable roles in almost all aspects of biology. Learn more about the new method for producing significant amounts of RNA labeled at specific sites…

Mutant HABP2 Causes Non-Medullary Thyroid Cancer

Cancer of the thyroid is the most common endocrine cancer and the eighth most common cancer in the U.S. Learn more about how mutant HABP2 causes non-medullary thyroid cancer…

Paradigm Shift in Thyroid Hormone Mechanism of Action

Thyroid hormone (TH) is one of the primary endocrine regulators of human metabolism and homeostasis. Learn more about the paradigm shift in thyroid hormone mechanisms of action…

Changes in Bacteria Induce Inflammatory Skin Diseases

Atopic dermatitis (AD) is a chronic inflammatory skin disease that manifests as dry skin with a relentless itch and eczema. Learn more about how changes in bacteria induce inflammatory skin diseases…

CCR In The Journals Archive

Note: All questions should be directed to TellCCR