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DNA Damage Repair Factors have a Tumor Promoting Role in MLL-fusion Leukemia

Cancers develop when cells accumulate DNA mutations that allow them to grow and divide inappropriately. Learn how DNA damage repair factors have a tumor promoting role in MLL-fusion leukemia…

COX-2 – A Novel Target for Reducing Tumor Angiogenesis and Metastasis

Angiogenesis is essential for tumor growth and metastasis, by supplying a steady stream of nutrients, removing waste, and providing tumor cells access to other sites in the body. Learn more about how COX-2 is a target for reducing tumor angiogenesis and metastasis…

Identifying Monoclonal Antibodies that Potently Inhibit MERS-CoV

Monoclonal antibodies (MAbs) may be a promising candidate for inhibiting MERS-CoV. Learn more about monoclonal antibodies that potently inhibit MERS-CoV…

HIV Integration at Certain Sites in Host DNA is Linked to the Expansion and Persistence of Infected Cells

When the Human Immunodeficiency Virus (HIV) infects a cell, the virus inserts a copy of its genetic material into the host cell’s DNA. Learn how HIV integration at certain sites in host DNA is linked to the expansion and persistence of infected cells…

Mitochondrial Enzyme Plays Critical Role in Chemotherapy-Induced Heart Damage

Mitochondria are the only organelles, aside from the nucleus, that contain actively replicated and transcribed DNA, even in differentiated cells. Learn more about how mitochondrial enzyme plays critical role in chemotherapy-induced heart damage…

Novel Structure of Ty3 Reverse Transcriptase

Ty3, a yeast LTR retrotransposon, encodes an RT that has been studied extensively for its biochemical activity and substrate binding interactions. Learn more about the novel structure of Ty3 Reverse Transcriptase…

Investigating the Role of NOS2 in Breast Cancer

Inducible nitric oxide synthase (NOS2) is often elevated in breast tumors that lack expression of the estrogen receptor (ER) and predicts a poor prognosis for patients with these tumors. Learn more the role of NOS2 in breast cancers…

Large Population-Based Study Reveals Disparities in Myeloma Precursor Disease

African Americans are more than twice as likely as whites to develop Mutiple Myeloma (MM), but the reason for this higher prevalence is not entirely clear. Learn more about how large population-based studies reveal disparities in myeloma precursor disease…

Small Molecule Disrupts Abnormal Gene Fusion Associated with Leukemia

Rare chromosomal abnormalities, called chromosomal translocations, in which part of a chromosome breaks off and becomes attached to another chromosome, can result in the generation of chimeric proteins. Learn how small molecule disrupts abnormal gene fusion associated with leukemia…

Changes in miRNAs Signal High-Risk HPV Infections

Numerous studies have shown that the levels of cellular miRNAs can be altered in diseased tissues, and these changes potentially could be used for diagnosis or disease monitoring. Learn more about how changes in miRNAs signal high-risk HPV infections…

Ionizing Radiation Enhances Monoclonal Antibody Effectiveness through Increased Target Expression

A type of targeted therapy, mAbs function by binding specific surface-expressed proteins and directly inhibiting their activity, often preventing cell proliferation, or inducing a cell-killing immune response called antibody-dependent cell-mediated cytotoxicity (ADCC). Learn more about how ionizing radiation enhances monoclonal antibody effectiveness through increased target expression…

Global Gene Expression Profiles Identify Metastasis Regulatory Networks

Metastasis is a systemic disease in which cancer cells break away from a tumor and migrate to other parts of the body, usually via the blood or lymphatic systems, to form new tumors. Learn more about how global gene expression profiles identify metastasis regulatory retworks…

Flipping the NF-κB Switch in Macrophages

A critical component of the innate immune system, macrophages respond to diverse microbes by recognizing certain molecular patterns, such as the Gram-negative bacteria product lipopolysaccharide (LPS), via Toll-like receptors. Read more about flipping the NF-κB switch in macrophages…

Cell Line Panel Reveals Repair Pathways Important to DNA Damaging Drugs

DNA topoisomerases I and II (Top1 and Top2) facilitate DNA replication by relaxing supercoiled DNA but use distinct mechanisms. Learn more about how cell line panels reveal repair pathways important to DNA damaging drugs…

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CCR In The Journals Archive