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Tumor-Protective Mechanism Identified from Premature Aging Disease

Patients with Hutchinson-Gilford Progeria Syndrome (HGPS) do not develop another aging-related disease, cancer, despite having dramatically elevated levels of DNA damage. Learn more about the tumor-protective mechanism identified from premature aging disease…

Inhibiting NANOG Enhances Efficacy of BH3 Mimetics

Abid Mattoo, Ph.D., J. Milburn Jessup, M.D., and colleagues of CCR’s Laboratory of Experimental Carcinogenesis, hypothesized that combining NANOG or NANOGP8 inhibition with a BH3 mimetic would enhance the latter’s anticancer activity. Learn more about how inhibiting NANOG enhances efficacy of BH3 mimetics…

Investigating Genetic Alterations in Bladder Cancer

Bladder cancer (BC) is the fifth most common cancer worldwide and the sixth most common cancer in the U.S. Read more about genetic alterations in bladder cancer…

Histone Variant Regulates DNA Repair via Chromatin Condensation

Activating the appropriate DNA repair pathway is essential for maintaining the stability of the genome after a break in both strands of DNA. Learn more about DNA repair via chromatin condensation…

DNA Damage Repair Factors have a Tumor Promoting Role in MLL-fusion Leukemia

Cancers develop when cells accumulate DNA mutations that allow them to grow and divide inappropriately. Learn how DNA damage repair factors have a tumor promoting role in MLL-fusion leukemia…

COX-2 – A Novel Target for Reducing Tumor Angiogenesis and Metastasis

Angiogenesis is essential for tumor growth and metastasis, by supplying a steady stream of nutrients, removing waste, and providing tumor cells access to other sites in the body. Learn more about how COX-2 is a target for reducing tumor angiogenesis and metastasis…

Identifying Monoclonal Antibodies that Potently Inhibit MERS-CoV

Monoclonal antibodies (MAbs) may be a promising candidate for inhibiting MERS-CoV. Learn more about monoclonal antibodies that potently inhibit MERS-CoV…

HIV Integration at Certain Sites in Host DNA is Linked to the Expansion and Persistence of Infected Cells

When the Human Immunodeficiency Virus (HIV) infects a cell, the virus inserts a copy of its genetic material into the host cell’s DNA. Learn how HIV integration at certain sites in host DNA is linked to the expansion and persistence of infected cells…

Mitochondrial Enzyme Plays Critical Role in Chemotherapy-Induced Heart Damage

Mitochondria are the only organelles, aside from the nucleus, that contain actively replicated and transcribed DNA, even in differentiated cells. Learn more about how mitochondrial enzyme plays critical role in chemotherapy-induced heart damage…

Novel Structure of Ty3 Reverse Transcriptase

Ty3, a yeast LTR retrotransposon, encodes an RT that has been studied extensively for its biochemical activity and substrate binding interactions. Learn more about the novel structure of Ty3 Reverse Transcriptase…

Investigating the Role of NOS2 in Breast Cancer

Inducible nitric oxide synthase (NOS2) is often elevated in breast tumors that lack expression of the estrogen receptor (ER) and predicts a poor prognosis for patients with these tumors. Learn more the role of NOS2 in breast cancers…

Large Population-Based Study Reveals Disparities in Myeloma Precursor Disease

African Americans are more than twice as likely as whites to develop Mutiple Myeloma (MM), but the reason for this higher prevalence is not entirely clear. Learn more about how large population-based studies reveal disparities in myeloma precursor disease…

Small Molecule Disrupts Abnormal Gene Fusion Associated with Leukemia

Rare chromosomal abnormalities, called chromosomal translocations, in which part of a chromosome breaks off and becomes attached to another chromosome, can result in the generation of chimeric proteins. Learn how small molecule disrupts abnormal gene fusion associated with leukemia…

Changes in miRNAs Signal High-Risk HPV Infections

Numerous studies have shown that the levels of cellular miRNAs can be altered in diseased tissues, and these changes potentially could be used for diagnosis or disease monitoring. Learn more about how changes in miRNAs signal high-risk HPV infections…

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CCR In The Journals Archive