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Immunotoxin Targeting Glypican-3 Effective against Liver Tumors

Worldwide, liver cancer is the fifth most common malignancy, and hepatocellular carcinoma (HCC) makes up about two-thirds of those cases. Learn more about how immunotoxin targeting glypican-3 can be effective against liver tumors…

Identifying a New Mechanism of HIV Core Formation

During the maturation of human immunodeficiency virus 1 (HIV-1), viral particles transition from a noninfectious form to an infectious one, and this conversion requires the cleavage of the HIV-1 Gag polyprotein. Learn more about how to identify new mechanisms of HIV core formation…

p53 Regulates Bone Differentiation and Osteosarcoma Formation

Osteosarcoma is an uncommon cancer that usually begins in the large bones of the arm or leg, but is the second leading cause of cancer-related death in children and young adults. Learn how p53 regulates bone differentiation and osteosarcoma formation…

Small RNA Enhances Antitumor T-cell Therapy

Adoptive T-cell transfer is an effective form of anticancer immunotherapy in which patients receive infusions of cytotoxic T cells that seek out and destroy targeted cancer cells. Learn more about how small RNA enhances antitumor t-cell therapy…

First-in-Human Study of Interleukin-15 as Immunotherapy for
Metastatic Cancer

One of the hallmarks of cancer that is now more clearly recognized is tumors’ ability to avoid recognition and destruction by the immune system. Learn more about the first-in-human study of interleukin-15 as immunotherapy for metastatic cancer…

Drosophila TDP1 Ortholog Important for Longevity and Nervous System Maintenance

As the molecule responsible for encoding a cell’s hereditary information, DNA must maintain its integrity. Learn more about the importance of drosophila TDP1 ortholog for longevity and nervous system maintenance…

CAR T Cell Immunotherapy Promising in Refractory Leukemia

Therapies that harness the power of the immune system are a more recent addition to the anticancer arsenal. Learn more about CAR T cell therapy, which genetically reprograms a patient’s own T cells to express a chimeric antigen receptor…

Designing and Testing Functional RNA Nanoparticles

Recent advances in nanotechnology have generated excitement that nanomaterials may provide novel approaches for the diagnosis and treatment of deadly diseases, such as cancer. Learn more about designing and testing functional RNA nanoparticles…

Finding Order in Randomness: Single-Molecule Studies Reveal Stochastic RNA Processing

Producing a functional eukaryotic messenger RNA (mRNA) requires the coordinated activity of several large protein complexes to initiate transcription, elongate nascent transcripts, splice together exons, and cleave and polyadenylate the 3’ end. Learn more about how single-molecule studies reveal stochastic RNA processing…

Tumor-Protective Mechanism Identified from Premature Aging Disease

Patients with Hutchinson-Gilford Progeria Syndrome (HGPS) do not develop another aging-related disease, cancer, despite having dramatically elevated levels of DNA damage. Learn more about the tumor-protective mechanism identified from premature aging disease…

Inhibiting NANOG Enhances Efficacy of BH3 Mimetics

Abid Mattoo, Ph.D., J. Milburn Jessup, M.D., and colleagues of CCR’s Laboratory of Experimental Carcinogenesis, hypothesized that combining NANOG or NANOGP8 inhibition with a BH3 mimetic would enhance the latter’s anticancer activity. Learn more about how inhibiting NANOG enhances efficacy of BH3 mimetics…

Investigating Genetic Alterations in Bladder Cancer

Bladder cancer (BC) is the fifth most common cancer worldwide and the sixth most common cancer in the U.S. Read more about genetic alterations in bladder cancer…

Histone Variant Regulates DNA Repair via Chromatin Condensation

Activating the appropriate DNA repair pathway is essential for maintaining the stability of the genome after a break in both strands of DNA. Learn more about DNA repair via chromatin condensation…

DNA Damage Repair Factors have a Tumor Promoting Role in MLL-fusion Leukemia

Cancers develop when cells accumulate DNA mutations that allow them to grow and divide inappropriately. Learn how DNA damage repair factors have a tumor promoting role in MLL-fusion leukemia…

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CCR In The Journals Archive