New HMGN Proteins Michael Bustin, Ph.D., 
Chief, Protein Section, LM, CCR, NCI, NIH
Home  |  NIH  |  bustin@helix.nih.gov
Comparative sequence analysis revealed the existence of several new HMGN nuclear proteins. The cellular function of these proteins is under investigation. Of particular interest is the new protein NSBP-1 (also named NP-45) (Shirakawa et al, JBC, 275, 6368, 2000) whose expression is developmentally regulated.

We found that HMGN proteins contain 3 functional domains:
NLS: A bipartite nuclear localization signal
NBD: A nucleosomal binding domain
Unfolding: A chromatin unfolding domain
small picture of the HMGB protein family
The HMGN protein family

Human HMGN3a
Human HMGN3b
Mouse HMGN3a
Mouse HMGN3b
Human HMGN4
Home  | HMG Proteins  |  Research Goals  |  Knock-out mice... 

 

chromatin unfolding...  |  Intracellular Trafficking...  |   Organization of HMG...
New HMG...  |  Linker Histone...  |  Modifications...  |  Development...

 

 

 


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Last revised on March 20, 2003 by Linda G. Byrd, Ph.D.

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