The Cellular Function of HMGN proteins: generation and analysis of HMGN knockout mice

We are generating mice lacking either the gene coding for HMGN1 (formerly named HMG-14), the gene coding for HMGN2 (formerly HMG-17), or both these genes. Studies on these mice and on cells derived from these mice provide insights into the cellular function and mechanism of action of the proteins. The cells are used to study the role of HMGN and other chromatin binding proteins in modulating, differentiation, development and oncogenic processes..

We are analyzing the cellular phenotype, the chromatin structure and the transcription profiles of tissues and cells of the HMGN knock-out mice.

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HMG Genes	HMGN1 Knockout Mice

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Last revised on July 18, 2003 by Linda G. Byrd, Ph.D.

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The Cellular Function of HMGN proteins: generation and analysis of HMGN knockout mice	Michael Bustin, Ph.D., Chief, Protein Section, LM, DBS, NCI, NIH

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