Linker Histone: HMG Interactions

Linker Histone H1:HMG Interactions in Living Cells

Michael Bustin, Ph.D.,
Chief, Protein Section, LM, CCR, NCI, NIH

We demonstrated that the sites of interaction of HMGN with nucleosomes partially overlap the binding sites of histone H1 in chromatin (Alfonso et al, J. Mol. Biol., 236, 189, 1994).

In collaboration with the Hansen Laboratory we demonstrated that HMGN1 counteracts the repressive activity of histone H1 (Ding et al, MCB, 17, 5843, 1997).

We are interested in the mechanism whereby possible H1-HMGN interactions affect the structure and function of chromatin.

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The chromatin binding sites of HMGN partially overlap with those of the linker histone H1	Microinjection of HMG proteins into H1-GFP expressing cells.

HMG:H1 dynamic network.

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Last revised on July 18, 2006 by Linda G. Byrd, Ph.D.

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