Mouse Strains available from the Laboratory of Metabolism

The following mouse strains are available from the Laboratory of Metabolism for scientific research after a Material Transfer Agreement (for academic institutions) or a biological license (for commercial applications) has been submitted and agreed to by Dr. Frank J. Gonzalez

The list supplies the following information:

The name of the mouse strain

• the affected gene
• the nature of the mutation (knock-out or transgenic)
• the notable phenotype(s)

HNF1-alpha

• hepatocyte nuclear factor 1 alpha
• knock-out
• Laron-type dwarfism, non-insulin dependent diabetes mellitus

C57PPAR-alpha

• peroxisome proliferator activated receptor-alpha
• knock-out
• none unless challenged

SV129PPAR-alpha

• peroxisome proliferator activated receptor-alpha
• knock-out
• none unless challenged

C57PPAR-beta

• peroxisome proliferator activated receptor-beta
• knock-out
• none unless challenged

HNF4-alpha

• hepatocyte nuclear factor 4 alpha
• conditional knock-out

C/ebp-alpha

• CCAAT/enhancer binding protein alpha
• conditional knock-out

C/ebp-beta

• CCAAT/enhancer binding protein beta
• knock-out

CYP1B1-null

• cytochrome p450 1B1
• knock-out
• none unless challenged

mEH

• Microsomal Epoxide Hydrolase
• knock-out
• none unless challenged

sEH

• Soluble Epoxide Hydrolase
• knock-out
• lower blood pressure in males

CYP1A2-High TG

• cytochrome p450 1A2 pancrease-specific expression
• Transgenic
• none

CYP1A2

• cytochrome p450 1A2
• knock-out
• none unless challenged

AHR

• aryl-hydrocarbon receptor
• knock-out
• 6 months of age develop skin problems, liver fibrosis and rectal prolapse

CYP 2E1

• cytochrome p450 2E1
• knock-out
• none unless challenged

NQO1

• NAD(P)H:quinone oxidoreductase 1
• knock-out
• none unless challenged

Arnt

• aromatic hydrocarbon receptor nuclear translocator
• conditional knock-out
• none unless challenged

FXR

• Farnesol X receptor
• knock-out and conditional knock-out
• serum bile acid accumulation; serum and liver lipid accumulation

T/ebp (TTF1, NKX2.1)

• Thyroid-specific enhancer-binding protein
• Knock -out
• organogenesis defects in thyroid, lung, and ventral forebrain

CYP2D6

• Cytochrome P450 2D6
• Transgenic

CYP3A4

• Cytochrome P450 3A4
• Transgenic

PPAR-gamma

• peroxisome proliferator activated receptor-gamma
• Conditional knock-out