Published Research
2011
Nghiemphu, P.L., Wen, P.Y., Lamborn, K.R., Drappatz, J., Robins, H.I., Fink, K., Malkin, M.G., Lieberman, F.S., Deangelis, L.M., Torres-Trejo, A., Chang, S.M., Abrey, L., Fine, H.A., Demopoulos, A., Lassman, A.B., Kesari, S., Mehta, M.P., Prados, M.D., and Cloughesy, T.F. 2010. A Phase I Trial of Tipifarnib with Radiation Therapy, with and without temozolomide, for Patients with Newly Diagnosed Glioblastoma. Int J Radiat Oncol Biol Phys. Epub ahead of print.
Riddick, G., Song, H., Ahn, S., Walling, J., Borges-Rivera, D., Zhang, W., and Fine, H.A. 2011. Predicting in vitro drug sensitivity using Random Forests. Bioinformatics. 27(2):220-4.
2010
Edwards, L.A., and Fine, H.A. 2010. The Ids have it. Cancer Cell. 18(6):543-5.
Sul, J., and Fine, H.A. 2010. Malignant gliomas: new translational therapies. Mt Sinai J Med. 77(6):655-66.
Wuchty, S., Zhang, A., Walling, J., Ahn, S., Li, A., Quezado, M., Oberholtzer, C., Zenklusen, J,C, and Fine, H.A. 2010. Gene pathways and subnetworks distinguish between major glioma subtypes and elucidate potential underlying biology. J Biomed Inform. 43(6):945-52.
Park, J.K., Hodges, T., Arko, L., Shen, M., Dello Iacono, D., McNabb, A., Olsen Bailey N., Kreisl, T.N., Iwamoto, F.M., Sul, J., Auh, S., Park, G.E., Fine, H.A., and Black, P.M. 2010. Scale to predict survival after surgery for recurrent glioblastoma multiforme. J Clin Oncol. 28(24):3838-43.
Li, A., Bozdag, S., Kotliarov, Y., and Fine, H.A. 2010. GliomaPredict: a clinically useful tool for assigning glioma patients to specific molecular subtypes. BMC Med Inform Decis Mak. 10:38.
Bozdag, S., Li, A., Wuchty, S., and Fine, H.A. 2010. FastMEDUSA: a parallelized tool to infer gene regulatory networks. Bioinformatics. 26(14):1792-3.
Rajaraman, P., Brenner, A.V., Neta, G., Pfeiffer, R., Wang, S.S., Yeager, M., Thomas, G., Fine, H.A., Linet, M.S., Rothman, N., Chanock, S.J., and Inskip, P.D. 2010. Risk of meningioma and common variation in genes related to innate immunity. Cancer Epidemiol Biomarkers Prev. 19(5):1356-61.
Kotliarov, Y., Bozdag, S., Cheng, H., Wuchty, S., Zenklusen, J.C., and Fine, H.A. 2010. CNAReporter: a GenePattern pipeline for the generation of clinical reports of genomic alterations. BMC Med Genomics. 3:11.
Iwamoto, F.M. and Fine, H.A. 2010. Bevacizumab for malignant gliomas. Arch Neurol. 67(3):285-8.
Iwamoto, F.M., Lamborn, K.R., Robins, H.I., Mehta, M.P., Chang, S.M., Butowski, N.A., Deangelis, L.M., Abrey, L.E., Zhang, W.T., Prados, M.D., and Fine, H.A. 2010. Phase II trial of pazopanib (GW786034), an oral multi-targeted angiogenesis inhibitor, for adults with recurrent glioblastoma (North American Brain Tumor Consortium Study 06-02). Neuro Oncol. 12(8):855-61.
Kreisl, T.N., Kotliarova, S., Butman, J.A., Albert, P.S., Kim, L., Musib, L., Thornton, D., and Fine, H.A. 2010. A phase I/II trial of enzastaurin in patients with recurrent high-grade gliomas. Neuro Oncol. 12(2):181-9.
Raizer, J.J., Abrey, L.E., Lassman, A.B., Chang, S.M., Lamborn, K.R., Kuhn, J.G., Yung, W.K., Gilbert, M.R., Aldape, K.A., Wen, P.Y., Fine, H.A., Mehta, M., Deangelis, L.M., Lieberman, F., Cloughesy, T.F., Robins, H.I., Dancey, J., Prados, M.D. 2010. A phase II trial of erlotinib in patients with recurrent malignant gliomas and nonprogressive glioblastoma multiforme postradiation therapy. Neuro Oncol. 12(1):95-103.
Raizer, J.J., Abrey, L.E., Lassman, A.B., Chang, S.M., Lamborn, K.R., Kuhn, J.G., Yung, W.K., Gilbert, M.R., Aldape, K.A., Wen, P.Y., Fine, H.A., Mehta, M., Deangelis, L.M., Lieberman, F., Cloughesy, T.F., Robins, H.I., Dancey, J., Prados, M.D. 2010. A phase I trial of erlotinib in patients with nonprogressive glioblastoma multiforme postradiation therapy, and recurrent malignant gliomas and meningiomas. Neuro Oncol. 12(1):87-94.
Iwamoto, F.M., Kreisl, T.N., Kim, L., Duic, J.P., Butman, J.A., Albert, P.S., and Fine, H.A. 2010. Phase 2 trial of talampanel, a glutamate receptor inhibitor, for adults with recurrent malignant gliomas. Cancer. 116(7):1776-82.
Wick, W., Puduvalli, V.K., Chamberlain, M.C., van den Bent, M.J., Carpentier, A.F., Cher, L.M., Mason, W., Weller, M., Hong, S., Musib, L., Liepa, A.M., Thornton, D.E., and Fine, H,A. 2010. Phase III study of enzastaurin compared with lomustine in the treatment of recurrent intracranial glioblastoma. J Clin Oncol. 28(7):1168-74.
2009
Grossman, S.A., Ye, X., Chamberlain, M., Mikkelsen, T., Batchelor, T., Desideri, S., Piantadosi, S., Fisher, J., and Fine, H.A. 2009. Talampanel with standard radiation and temozolomide in patients with newly diagnosed glioblastoma: a multicenter phase II trial. J Clin Oncol. 27(25):4155-61.
Woolard, K., and Fine, H.A. 2009. Glioma stem cells: better flat than round. Cell Stem Cell. 4(6):466-7.
Son, M.J., Woolard, K., Nam, D.H., Lee, J., and Fine, H.A. 2009. SSEA-1 is an enrichment marker for tumor-initiating cells in human glioblastoma. Cell Stem Cell. 4(5):440-52.
Kreisl, T.N., Kim, L., Moore, K., Duic, P., Kotliarova, S., Walling, J., Musib, L., Thornton, D., Albert, P.S., and Fine, H.A. 2009. A phase I trial of enzastaurin in patients with recurrent gliomas. Clin Cancer Res. 15(10):3617-23.
Fine, H.A. 2009. Glioma stem cells: not all created equal. Cancer Cell. 15(4):247-9.
Li, A., Walling, J., Ahn, S., Kotliarov, Y., Su, Q., Quezado, M., Oberholtzer, J.C., Park, J., Zenklusen, J.C., and Fine, H.A. 2009. Unsupervised analysis of transcriptomic profiles reveals six glioma subtypes. Cancer Res. 69(5):2091-9.
Madhavan, S., Zenklusen, J.C., Kotliarov, Y., Sahni, H., Fine, H.A., and Buetow, K. 2009. Rembrandt: helping personalized medicine become a reality through integrative translational research. Mol Cancer Res. 7(2):157-67.
Kotliarov, Y., Kotliarova, S., Charong, N., Li, A., Walling, J., Aquilanti, E., Ahn, S., Steed, M.E, Su, Q., Center, A., Zenklusen, J.C., and Fine, H.A. 2009. Correlation analysis between single-nucleotide polymorphism and expression arrays in gliomas identifies potentially relevant target genes. Cancer Res. 69(4):1596-603.
Kreisl, T.N., Kim, L., Moore, K., Duic, P., Royce, C., Stroud, I., Garren, N., Mackey, M., Butman, J.A., Camphausen, K., Park, J., Albert, P.S., and Fine, H.A. 2009. Phase II trial of single-agent bevacizumab followed by bevacizumab plus irinotecan at tumor progression in recurrent glioblastoma. J Clin Oncol. 27(5):740-5.
2008
Kotliarova, S., Pastorino, S., Kovell, L.C., Kotliarov, Y., Song, H., Zhang, W., Bailey, R., Maric, D., Zenklusen, J.C., Lee, J., and Fine, H.A. 2008. Glycogen synthase kinase-3 inhibition induces glioma cell death through c-MYC, nuclear factor-kappaB, and glucose regulation. Cancer Res. 68(16):6643-51.
Chang, S.M., Lamborn, K.R., Kuhn, J.G., Yung, W.K., Gilbert, M.R., Wen, P.Y., Fine, H.A., Mehta, M.P., DeAngelis, L.M., Lieberman, F.S., Cloughesy, T.F., Robins, H.I., Abrey, L.E., and Prados, M.D. 2008. Neurooncology clinical trial design for targeted therapies: lessons learned from the North American Brain Tumor Consortium. Neuro Oncol. 10(4):631-42.
Purow, B.W., Sundaresan, T.K., Burdick, M.J., Kefas, B.A., Comeau, L.D., Hawkinson, M.P., Su, Q., Kotliarov, Y., Lee, J., Zhang, W., and Fine, H.A. 2008. Notch-1 regulates transcription of the epidermal growth factor receptor through p53. Carcinogenesis. 29(5):918-25.
Lamborn, K.R., Yung, W.K., Chang, S.M., Wen, P.Y., Cloughesy, T.F., DeAngelis, L.M., Robins, H.I., Lieberman, F.S., Fine, H.A., Fink, K.L., Junck, L., Abrey, L., Gilbert, M.R., Mehta, M., Kuhn, J.G., Aldape, K.D., Hibberts, J., Peterson, P.M., and Prados, M.D. 2008. Progression-free survival: an important end point in evaluating therapy for recurrent high-grade gliomas. Neuro Oncol. 10(2):162-70.
Li, A., Walling, J., Kotliarov, Y., Center, A., Steed, M.E., Ahn, S.J., Rosenblum, M., Mikkelsen, T., Zenklusen, J.C., and Fine, H.A. 2008. Genomic changes and gene expression profiles reveal that established glioma cell lines are poorly representative of primary human gliomas. Mol Cancer Res. 6(1):21-30.
Lee, J., Son, M.J., Woolard, K., Donin, N.M., Li, A., Cheng, C.H., Kotliarova, S., Kotliarov, Y., Walling, J., Ahn, S., Kim, M., Totonchy, M., Cusack, T., Ene, C., Ma, H., Su, Q., Zenklusen, J.C., Zhang, W., Maric, D., and Fine, H.A. 2008. Epigenetic-mediated dysfunction of the bone morphogenetic protein pathway inhibits differentiation of glioblastoma-initiating cells. Cancer Cell. 13(1):69-80.
Fine, H.A., Kim, L., Albert, P.S., Duic, J.P., Ma, H., Zhang, W., Tohnya, T., Figg, W.D., and Royce, C. 2008. A phase I trial of lenalidomide in patients with recurrent primary central nervous system tumors. Clin Cancer Res. 13(23):7101-6.
Fine, H.A. 2008. Promising new therapies for malignant gliomas. Cancer J. 13(6):349-54.
2007
Brenner, A.V., Butler, M.A., Wang, S.S., Ruder, A.M., Rothman, N., Schulte, P.A., Chanock, S.J., Fine, H.A., Linet, M.S., Inskip, P.D 2007. Single-nucleotide polymorphisms in selected cytokine genes and risk of adult glioma. Carcinogenesis. 28(12):2543-7.
Rajaraman, P., Wang, S.S., Rothman, N., Brown, M.M., Black, P.M., Fine, H.A., Loeffler, J.S., Selker, R.G., Shapiro, W.R., Chanock, S.J., Inskip, P.D. 2007. Polymorphisms in apoptosis and cell cycle control genes and risk of brain tumors in adults. Cancer Epidemiol Biomarkers Prev. 16(8):1655-61.
Ngo, T.T., Peng, T., Liang, X.J., Akeju, O., Pastorino, S., Zhang, W., Kotliarov, Y., Zenklusen, J.C., Fine, H.A., Maric, D., Wen, P.Y., De Girolami, U., Black, P.M., Wu, W.W., Shen, R.F., Jeffries, N.O., Kang, D.W., Park, J.K. 2007. The 1p-encoded protein stathmin and resistance of malignant gliomas to nitrosoureas. J Natl Cancer Inst. 99(8):639-52.
Bluhm, E.C., Zahm, S.H., Fine, H.A., Black, P.M., Loeffler, J.S., Shapiro, W.R., Selker, R.G., Inskip, P.D. 2007. Personal hair dye use and risks of glioma, meningioma, and acoustic neuroma among adults. Am J Epidemiol. 165(1):63-71.
2006
Rajaraman, P., Stewart, P.A., Samet, J.M., Schwartz, B.S., Linet, M.S., Zahm, S.H., Rothman, N., Yeager, M., Fine, H.A., Black, P.M., Loeffler, J., Shapiro, W.R., Selker, R.G., Inskip, P.D. 2006. Lead, genetic susceptibility, and risk of adult brain tumors. Cancer Epidemiol Biomarkers Prev. 15(12):2514-20.
Kotliarov, Y., Steed, M.E., Christopher, N., Walling, J., Su, Q., Center, A., Heiss, J., Rosenblum, M., Mikkelsen, T., Zenklusen, J.C., Fine, H.A. 2006. High-resolution global genomic survey of 178 gliomas reveals novel regions of copy number alteration and allelic imbalances. Cancer Res. 66(19):9428-36.
Wen, P.Y., Yung, W.K., Lamborn, K.R., Dahia, P.L., Wang, Y., Peng, B., Abrey, L.E., Raizer, J., Cloughesy, T.F., Fink, K., Gilbert, M., Chang, S., Junck, L., Schiff, D., Lieberman, F., Fine, H.A., Mehta, M., Robins, H.I., DeAngelis, L.M., Groves, M.D., Puduvalli, V.K., Levin, V., Conrad, C., Maher, E.A., Aldape, K., Hayes, M., Letvak, L., Egorin, M.J., Capdeville, R., Kaplan, R., Murgo, A.J., Stiles, C., Prados, M.D. 2006. Phase I/II study of imatinib mesylate for recurrent malignant gliomas: North American Brain Tumor Consortium Study 99-08. Clin Cancer Res. 12(16):4899-907.
Lee, J., Kotliarova, S., Kotliarov, Y., Li, A., Su, Q., Donin, N.M., Pastorino, S., Purow, B.W., Christopher, N., Zhang, W., Park, J.K., Fine, H.A. 2006. Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines. Cancer Cell. 9(5):391-403.
Sun, L., Hui, A.M., Su, Q., Vortmeyer, A., Kotliarov, Y., Pastorino, S., Passaniti, A., Menon, J., Walling, J., Bailey, R., Rosenblum, M., Mikkelsen, T., Fine, H.A. 2006. Neuronal and glioma-derived stem cell factor induces angiogenesis within the brain. Cancer Cell. 9(4):287-300.
De Roos, A.J., Rothman, N., Brown, M., Bell, D.A., Pittman, G.S., Shapiro, W.R., Selker, R.G., Fine, H.A., Black, P.M., Inskip, P.D. 2006. Variation in genes relevant to aromatic hydrocarbon metabolism and the risk of adult brain tumors. Neuro Oncol. 8(2):145-55.
Prados, M.D., Lamborn, K., Yung, W.K., Jaeckle, K., Robins, H.I., Mehta, M., Fine, H.A., Wen, P.Y., Cloughesy, T., Chang, S., Nicholas, M.K., Schiff, D., Greenberg, H., Junck, L., Fink, K., Hess, K., Kuhn, J.; North American Brain Tumor Consortium. 2006. A phase 2 trial of irinotecan (CPT-11) in patients with recurrent malignant glioma: a North American Brain Tumor Consortium study. Neuro Oncol. 8(2):189-93.
Cho, S.Y., Ravasi, L., Szajek, L.P., Seidel, J., Green, M.V., Fine, H.A., Eckelman, W.C. 2006. Evaluation of (76)Br-FBAU as a PET reporter probe for HSV1-tk gene expression imaging using mouse models of human glioma. J Nucl Med. 46(11):1923-30.
Glod, J., Kobiler, D., Noel, M., Koneru, R., Lehrer, S., Medina, D., Maric, D., Fine, H.A. 2006. Monocytes form a vascular barrier and participate in vessel repair after brain injury. Blood. 107(3):940-6.
For older articles, see Dr. Fine’s publications in PubMed.