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Mission Statement |
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The
overall mission of the Oncogenomics section of the Pediatric Oncology Branch, is to leverage the power of genome wide high-throughput
approaches to improve the outcome of patients with high risk cancers, with a
focus on neuroblastoma. Research Goals of the Oncogenomics Section of the
Pediatric Oncology Branch 1. Applying high
throughput genomics and proteomics to characterize high risk pediatric
malignancies, focusing on neuroblastoma. 2. Identification of
novel diagnostic and prognostic biomarkers and targets, validation of novel
targets and translation to the clinic. 3. Systems Biology of
Neuroblastoma to decipher the complex interactions of DNA copy number, DNA
mutations, messenger RNA (mRNA), micro RNA (miRNA) and protein with the
cancer phenotype. 4. Public release of data
to stimulate collaborative research and maximally utilize high quality data
generated by our section and other investigators in the field. 5. Technology Development To achieve these goals we are applying DNA
microarray-based and other high throughput techniques including:
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