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Featured Videos on Cancer Research at NCI

photo of Dr. James Gulley

Camera on Cancer Research: Studying Cell Motility to Combat Cancer

Carole Parent, Ph.D., a Senior Investigator in CCR’s Laboratory of Cellular and Molecular Biology, studies mechanisms of cell motility to learn about how cancer cells can migrate throughout the body. Her live cell imaging of these cells reveals the mechanics of their migration, which may become the basis for treatments against metastasis. Learn more about Dr. Parent’s research

photo of Dr. Marston Linehan

Camera on Cancer Research: Targeting the Metabolic Basis of Kidney Cancer

Dr. Marston Linehan, Chief of CCR’s Urologic Oncology Branch, discusses how his group’s study of a thousand families with kidney cancer led to the discovery of the genes that cause this disease. Listen to Dr. Linehan as talks about his leading The Cancer Genome Atlas’s characterization of the most common type of kidney cancer called clear cell kidney carcinoma, which uncovered the metabolic basis of this disease. Learn more about Dr. Linehan’s research

photo of Dr. Andrea Apolo

Camera on Cancer Research: Attacking Bladder Cancer on Multiple Fronts

Andrea Apolo, M.D., an Investigator in CCR’s Genitourinary Malignancies Branch, discusses her clinical trials and lab research focused on bladder cancer. She conducts clinical trials on medications that inhibit the blood supply to tumors and medications that focus on the MET pathway and trials that seek to find the best medication for a patient given their genetic makeup. She is also working on techniques for visualizing tumors in three dimensions in order to better characterize tumor growth and patient response to treatment. Learn more about Dr. Apolo’s research

photo of Dr. Bruce Shapiro

Camera on Cancer Research: Designing RNA Nanoscaffolds to Deliver Drugs

Dr. Bruce Shapiro, a Senior Investigator in CCR’s Basic Research Laboratory, takes you into his lab where he develops nanoscale tools to take advantage of the ability of a kind of RNA called RNAi to silence genes. He constructs nanostructures out of RNA and DNA building blocks to deliver RNAi to specific locations in the body. The result is a customizable method for targeting particular genes within individual tumors or other diseased tissues. Learn more about Dr. Shapiro’s research

photo of Dr. Peter Choyke

Camera on Cancer Research: Using Photoimmunotherapy to Fight Cancer

Peter Choyke, M.D., Director of CCR’s Molecular Imaging Program, discusses a cancer therapy that he developed with his colleague Hisataka Kobayashi, M.D., Ph.D., called photoimmunotherapy. This therapy involves attaching a photosensitizer to an antibody that can selectively target cancer cells. Once in place, the photosensitizer/antibody complex can be activated with infrared light, essentially destroying the cancer cell, but leaving nearby normal cells unharmed. Learn more about Dr. Choyke’s research

photo of Dr. James Gulley

Camera on Cancer Research: Using a Cancer Vaccine to Provide Hope

Dr. James Gulley, Director of CCR's Clinical Immunotherapy Group, takes you into his clinic where he plans and conducts numerous clinical trials using cancer vaccines to treat and prevent cancer. You will hear from three of Dr. Gulley's patients currently enrolled in his clinical trials. While each patient shares their story, you will get a better understanding of the drive and passion behind Dr. Gulley's research. Learn more about Dr. Gulley’s research

photo of Dr. Kathleen Kelly

Camera on Cancer Research: Helping Fight Metastatic Prostate Cancer

Dr. Kathleen Kelly, Branch Chief of CCR's Cell and Cancer Biology Branch, takes you into her lab where she researches the biology and origin of metastatic prostate cancer cells. Watch and listen to Dr. Kelly as she explains her interest in better understanding the signaling pathways that mediate cancer progression and metastasis. Learn more about Dr. Kelly’s research

photo of Dr. Gordon Hager

Camera on Cancer Research: Using Receptor Biology to Understand the Complexities of Cancer

Dr. Gordon Hager, Chief of CCR's Laboratory of Receptor Biology and Gene Expression, takes you into his lab where he researches nuclear hormone receptors and their role in modulating the chromatin structure in gene regulation. Watch and listen as Dr. Hager uses living cell technology to better understand the molecular detail of how these processes take place. Learn more about Dr. Hager's research

photo of Dr. Len Neckers

Camera on Cancer Research: Hsp90 Inhibitors, Powerful Drugs in the Fight Against Cancer

Dr. Len Neckers, Senior Investigator in CCR's Urologic Oncology Branch, takes you into his lab where he researches the role of chaperone proteins in signal transduction. Dr. Neckers studies the chaperone Hsp90, and has over the years developed Hsp90 inhibitors as novel anti-cancer agents. Watch and listen to Dr. Neckers' progress in developing the next generation of Hsp90 inhibitors to be used as powerful drugs in the fight against cancer. Learn more about Dr. Neckers' research

photo of Dr. Carole Parent

Teaming Up to Fight Cancer

Dr. Carole Parent, Senior Investigator of CCR's Laboratory of Cellular and Molecular Biology discusses the 2010 signing of the Graduate Partnership Program in Cancer Technology. This agreement allows Dr. Parent and other NCI researchers to collaborate with University of Maryland students studying physics and math in hopes of encouraging groundbreaking cancer research. In the video, you will meet University of Maryland physics student Colin McCann, who is currently collaborating with Dr. Parent. Learn more about Dr. Parent's research. Read about the NCI/UMD collaboration in CCR Connections.

photo of Dr. Genoveffa Franchini

Using Vaccines to Tackle HIV

Dr. Genoveffa Franchini, Senior Investigator in the Vaccine Branch at the National Cancer Institute's (NCI) Center for Cancer Research (CCR), discusses the Cooperative Research and Development Agreement (CRADA) between NCI and the pharmaceutical company, Sanofi Pasteur. This CRADA allowed for the development of a vaccine approach that reduced the risk of HIV infection. The results were shown in one of the largest HIV intervention trials to date. Learn more about Dr. Franchini's research. Read the HIV vaccine story in CCR Connections.

photo of Dr. Carol Thiele

Camera on Cancer Research: Unraveling the Molecular Mechanisms of Neuroblastoma

Dr. Carol Thiele, Head of the Cell and Molecular Biology Section in the Pediatric Oncology Branch, takes you into her lab where she researches the molecular mechanisms of neuroblastoma cells. Dr. Thiele studies whether these cells proliferate or differentiate in response to various compounds, a key factor for developing new therapeutic approaches to treat neuroblastoma. Watch and listen to Dr. Thiele's progress in discovering less toxic and more effective therapies for neuroblastoma patients. Learn more about Dr. Thiele's research.

photo of Dr. Sheue-yann Cheng

Camera on Cancer Research: Using Mice Models to Fight Thyroid Cancer

Dr. Sheue-yann Cheng, Head of the Gene Regulation Section in the Laboratory of Molecular Biology, takes you into her lab where she researches the biology and molecular actions of thyroid hormone receptors in health and disease. Dr. Cheng uses mouse models to study resistance to thyroid hormone (RTH), a key step in cancer development. Watch and listen to Dr. Cheng's passion for uncovering possible molecular targets for the treatment of thyroid cancer. Learn more about Dr. Cheng's research.

photo of Dr. Natasha Caplen

Camera on Cancer Research: Using Genetics to Help fight Cancer

Dr. Natasha Caplen, Head of the Gene Silencing Section in CCR's Genetic Branch, walks you through her lab and explains how she uses a gene silencing mechanism called RNA interference (RNAi) to selectively switch off one gene at a time. This technology allows her to discover a gene's function. Caplen uses this information to find new cancer treatment targets and possible agents that can block these targets. Learn more about Dr. Caplen's research.