To:                                                                                X-Ray NIH

Subject: Newsletter 504 (December 18, 2023) NIH X-ray Diffraction SIG

 

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NOVEMBER 2023 PUBLICATIONS BY MEMBERS OF THE GROUP

 

1: Myr-Arf1 conformational flexibility at the membrane surface sheds light on the interactions with ArfGAP ASAP1.

Zhang Y, Soubias O, Pant S, Heinrich F, Vogel A, Li J, Li Y, Clifton LA, Daum S, Bacia K, Huster D, Randazzo PA, Lösche M, Tajkhorshid E, Byrd RA.

Nat Commun. 2023 Nov 21;14(1):7570.

doi: 10.1038/s41467-023-43008-5. PMID: 37989735.

 

2: Intra- and inter-molecular regulation by intrinsically-disordered regions governs PUF protein RNA binding.

Qiu C, Zhang Z, Wine RN, Campbell ZT, Zhang J, Hall TMT.

Nat Commun. 2023 Nov 13;14(1):7323.

doi: 10.1038/s41467-023-43098-1. PMID: 37953271.

 

3: Antibody-directed evolution reveals a mechanism for enhanced neutralization at the HIV-1 fusion peptide site.

Banach BB, Pletnev S, Olia AS, Xu K, Zhang B, Rawi R, Bylund T, Doria-Rose NA, Nguyen TD, Fahad AS, Lee M, Lin BC, Liu T, Louder MK, Madan B, McKee K, O'Dell S, Sastry M, Schön A, Bui N, Shen CH, Wolfe JR, Chuang GY, Mascola JR, Kwong PD, DeKosky BJ.

Nat Commun. 2023 Nov 21;14(1):7593.

doi: 10.1038/s41467-023-42098-5. PMID: 37989731.

 

4: High frequency of HIV precursor-target-specific B cells in sub-Saharan populations.

Matassoli F, Cagigi A, Shen CH, Henry AR, Johnston TS, Schramm CA, Cottrell CA, Kalyuzhniy O, Spangler A, Eller L, Robb M, Eller M, Naluyima P, Kwong PD, Douek DC, Schief WR, Andrews SF, McDermott AB.

Cell Rep. 2023 Nov 28;42(12):113450.

doi: 10.1016/j.celrep.2023.113450. PMID: 38019653

 

 

METHODS – Cryo-EM, in Rational Design of Hybrid Inhibitors

 

M. Kschonsak et al., “Cryo-EM reveals an unprecedented binding site for Nav1.7 inhibitors enabling rational design of potent hybrid inhibitors” PMID: 36975198.

 

 

READINGS & TUTORIALS – Macromolecular Crystallography

 

D.J. Haas, “Fifty years on: why macromolecular cryocrystallography has been so successful” IUCr Newsletter (2023) 31(3).

 

W.A. Hendrickson, “Facing the phase problem” PMID: 37668214.

 

 

DATABASES – Structural Biology


AlphaFold DB, BioCyc, DisProt, ExPASy, HAD, HIC-Up, NDB, PDB, PDBe, PDB SARS-CoV-2 Resources, SARS-CoV-2 Related Structures, RaMP-DB, virusMED,

 

Xinhua Ji, Ph.D.

Senior Investigator

National Cancer Institute, NIH

Phone: (301) 846-5035