To:                                                                                X-Ray NIH

Subject: Newsletter 505 (January 1, 2024) NIH X-ray Diffraction SIG

 

 

 

DECEMBER 2023 PUBLICATIONS BY MEMBERS OF THE GROUP

 

1: Gerard L, Duviver L, Fourrez M, Salazar P, Sprimont L, Xia D, Ambudkar SV, Gottesman MM, Gillet JP.

Identification of two novel heterodimeric ABC transporters in melanoma: ABCB5β/B6 and ABCB5β/B9.

J Biol Chem. 2023 Dec 23:105594.

doi: 10.1016/j.jbc.2023.105594. Epub ahead of print. PMID: 38145744.

 

2: Schramm CA, Moon D, Peyton L, Lima NS, Wake C, Boswell KL, Henry AR, Laboune F, Ambrozak D, Darko SW, Teng IT, Foulds KE, Carfi A, Edwards DK, Kwong PD, Koup RA, Seder RA, Douek DC.

Interaction dynamics between innate and adaptive immune cells responding to SARS-CoV-2 vaccination in non-human primates.

Nat Commun. 2023 Dec 2;14(1):7961.

doi: 10.1038/s41467-023-43420-x. PMID: 38042809; PMCID: PMC10693617.

 

3: Folco HD, Xiao H, Wheeler D, Feng H, Bai Y, Grewal SIS.

The cysteine-rich domain in CENP-A chaperone Scm3HJURP ensures centromere targeting and kinetochore integrity.

Nucleic Acids Res. 2023 Dec 12:gkad1182.

doi: 10.1093/nar/gkad1182. Epub ahead of print. PMID: 38084929.

 

4: Boyd LF, Jiang J, Ahmad J, Natarajan K, Margulies DH.

Experimental structures of antibody/MHC-I complexes reveal details of epitopes overlooked by computational prediction.

bioRxiv [Preprint]. 2023 Dec 4:2023.12.01.569627.

doi: 10.1101/2023.12.01.569627. PMID: 38106040; PMCID: PMC10723347.

 

5: Garrett SR, Mietrach N, Deme J, Bitzer A, Yang Y, Ulhuq FR, Kretschmer D, Heilbronner S, Smith TK, Lea SM, Palmer T.

A type VII-secreted lipase toxin with reverse domain arrangement.

Nat Commun. 2023 Dec 19;14(1):8438.

doi: 10.1038/s41467-023-44221-y. PMID: 38114483; PMCID: PMC10730906.

 

6: Osei-Amponsa V, Chandravanshi M, Lu X, Magidson V, Das S, Andresson T, Dyba M, Sabbasani VR, Swenson RE, Fromont C, Shrestha B, Zhao Y, Clapp ME, Chari R, Walters KJ.

hRpn13 shapes the proteome and transcriptome through epigenetic factors HDAC8, PADI4, and transcription factor NF-κB p50.

Mol Cell. 2023 Dec 20:S1097-2765(23)00980-2.

doi: 10.1016/j.molcel.2023.11.035. Epub ahead of print. PMID: 38151017.

 

 

METHODS – Cryo-EM, in Rational Design of Hybrid Inhibitors

 

M. Kschonsak et al., “Cryo-EM reveals an unprecedented binding site for Nav1.7 inhibitors enabling rational design of potent hybrid inhibitors” PMID: 36975198.

 

 

READINGS & TUTORIALS – Macromolecular Crystallography

 

D.J. Haas, “Fifty years on: why macromolecular cryocrystallography has been so successful” IUCr Newsletter (2023) 31(3).

 

W.A. Hendrickson, “Facing the phase problem” PMID: 37668214.

 

 

DATABASES – Structural Biology

AlphaFold DB, BioCyc, DisProt, ExPASy, HAD, HIC-Up, NDB, PDB, PDBe, PDB SARS-CoV-2 Resources, SARS-CoV-2 Related Structures, RaMP-DB, virusMED,

 

Xinhua Ji, Ph.D.

Senior Investigator

National Cancer Institute, NIH

Phone: (301) 846-5035