Newsletter 549 (September 1, 2026) NIH Structural Biology Methods SIG

AUGUST 2026 PUBLICATIONS BY MEMBERS OF THE GROUP

1: Mangione CC, Klein MG, Fatima N, Belous N, Mayer M, Nwachukwu P, Melvin BM, Burnett BG, Flagg TP.
SMN deficiency causes cardiac adrenergic insensitivity via activation of the cAMP-PKA pathway.
Neurobiology of disease 2026-08-26 doi: 10.1016/j.nbd.2026.107587 PMID: 42648444

2: Park ZM, Savage CR, Decker-Farrell AR, Tai CH, Maity TK, Yang W, Jenkins LM, Ramamurthi KS.
16S ribosomal RNA modification drives transcript-specific translation efficiency.
Cell reports 2026-08-22 doi: 10.1016/j.celrep.2026.117887 PMID: 42632017

3: Runge B, Oktay H, Fucci IJ, Merten EM, Tarasov SG, Fan L, Monteiro DCF.
Robust structural, kinetic and biophysical characterization of wild-type human ACOD1, selected mutants and their interaction with citraconate.
Journal of structural biology: X 2026-08-22 doi: 10.1016/j.yjsbx.2026.100157 PMID: 42631184

4: DeCuir J, Reeves EL, Weber ZA, Yang DH, Irving SA, Tartof SY, Klein NP, Grannis SJ, Ong TC, Ball SW, DeSilva MB, Dascomb K, Naleway AL, Koppolu P, Salas SB, Sy LS, Lewin B, Contreras R, Zerbo O, Hansen JR, Block L, Jacobson KB, Dixon BE, Rogerson C, Duszynski T, Fadel WF, Barron MA, Mayer D, Chavez C, Yates A, Kirshner L, McEvoy CE, Akinsete OO, Essien IJ, Sheffield T, Bride D, Arndorfer J, Van Otterloo J, Natarajan K, Ray CS, Payne AB, Adams K, Flannery B, Garg S.
Influenza Vaccine Effectiveness Against Influenza-Associated Hospitalizations and Emergency Department or Urgent Care Encounters Among Children and Adults-VISION, United States, 2024-2025 Season.
Open forum infectious diseases 2026-08-19 doi: 10.1093/ofid/ofag473 PMID: 42614619

5: Joshi C, Deme JC, Nakamura Y, Hsu WT, Goult JD, Kato T, Parker JL, Biggin PC, Lea SM, Nakanishi T, Newstead S.
Author Correction: Structural basis for prostaglandin and drug transport via SLCO2A1.
Nature communications 2026-08-18 doi: 10.1038/s41467-026-76870-0 PMID: 42608403

6: Cheng J, Cale EM, Maghsoudi A, Sutton MS, Longo NS, Gillespie RA, Wang L, Kosik I, Chong S, Yasuhara A, Bylund T, Schön A, Tripathi P, Tsybovsky Y, Lei H, Morano NC, Lupatkin AB, Morton AJ, Lang ZC, Becker JE, Frascilla IR, Lee M, Li N, Liu C, Roark RS, Shen CH, Teng IT, Van Wazer DJ, Wang D, Wu L, Ahlsen G, Castro M, Du H, Ernandes MJ, Li T, Lin BC, Louder MK, McKee K, Merriam JS, O'Dell S, Ou L, Pletnev S, Prikryl D, Qiu Q, Rubin S, Sastry M, Schmidt SD, Shajahan A, Shiakolas AR, Srivatsan S, Zhang B, Zhou Q, Connors M, Gall JG, Guo Y, Huang RK, Huang Y, Koup RA, Lei QP, Mascola JR, Rawi R, Serebryannyy L, Shapiro L, Sheng Z, Ho DD, Wilson PC, Yewdell JW, Pierson TC, Kanekiyo M, Doria-Rose NA, Kwong PD, Zhou T.
Canonical Antibodies Adopt Distinct Binding Modes to Recognize Viral Glycan Shields.
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026-08-14 doi: 10.1002/advs.77172 PMID: 42598737

7: Espinosa JM, Burdekin K, Auman JO, Tyndall B, Cnota JF, Hartley SL, Fidler DJ, Redline S, Thessen A, Catellier D, Carroll RJ, Rosser T, Lo P, Beaumont D, Natarajan K, Heath A, Fabbri D, Dunford MC, Cheng A, Schwartz B, Li H.
Common data element (CDE) and AI-Enabled approaches for clinical data Management: Workshop proceedings from the NIH INCLUDE Project.
Journal of biomedical informatics 2026-08-12 doi: 10.1016/j.jbi.2026.105090 PMID: 42586352

8: Koo JH, Tripathi P, Flores-Garcia Y, Miura K, Bayarsaikhan G, Shen CH, Weldon SR, Kratochvil S, Prum T, Albowaidey AA, Kim YJ, Ellis-Pugh JR, Phan QA, Suurbaar J, Onjiko RS, Choe M, Dale GA, Lei H, Morano NC, Da Silva Pereira L, Dillon M, Bender MF, Lofgren M, Zhang B, Pierson TC, Shapiro L, Zhou T, Nair U, Idris AH, Zavala F, Kwong PD, Seder RA, Batista FD.
Overcoming immunogenic gaps in malaria subunit vaccines by broadening CSP regions targeted.
The Journal of experimental medicine 2026-08-07 doi: 10.1084/jem.20260846 PMID: 42565808

9: Zhang L, Lee AE, Tian E, Collins MT, Roszko KL, Samara NL, Ten Hagen KG.
Mechanistic insights into mutations that cause diseases of phosphate dysregulation.
Proceedings of the National Academy of Sciences of the United States of America 2026-08-05 doi: 10.1073/pnas.2603453123 PMID: 42555639

10: None None, Razo C, DeCleene NK, Johnson CO, Stark BA, LeGrand K, Aalruz H, Abaraogu UO, Abd ElHafeez S, Abdelmasseh M, Abdelnabi M, Abd-Elsalam S, Abdelsalam Elshenawy R, Abdelwahab SI, Abdolizadeh A, Abdollahi A, Abdoun M, Abdrabou MM, Abdulah DM, Abdullahi A, Abdul-Rahman T, Abebe MS, Abebe Getahun H, Abiodun OO, Abiodun O, Abohashem S, Abonie US, Abourashed NM, Abramov D, Abrar MM, Abtahi D, Abu Farha RK, Abubakar B, Abuhelwa AY, Abukhadijah HJ, Aburuz S, Abushanab D, Adams LC, Adamu NLL, Adane MM, Addo IY, Adedokun KA, Adegbile OE, Adegoke NA, Adekola SA, Adeleke OT, Adesina MA, Adisu MA, Adnan M, Afoakwah C, Afolabi AA, Afrashteh F, Afrifa-Yamoah E, Afzal S, Agordoh PD, Agyemang-Duah W, Ahmad A, Ahmad K, Ahmad S, Ahmad S, Ahmed A, Ahmed GS, Ahmed LA, Ahmed MS, Ahmed MS, Ahmed MSA, Ahmed M, Ahmed N, Ahmed SA, Ahmed Z, Aiyer A, Ajami M, Akalanka KHM, Akhtar MN, Akindele MO, Akkaif MA, Akrami AE, Akyea RK, Al Hasan SM, Al Zoubi MAM, Alahdab F, Al-Ahmad MM, Alajajian S, Alajlani MM, Alalwan TA, Al-Aly Z, Al-Amri IS, Alanzi TM, Alarifi A, Al-Ashwal FY, Al-Azayzih A, Al-Azzam S, Al-Bashaireh AM, Albashtawy M, Al-Dewik N, Aleidi SM, Algahtani FD, Algammal AM, Alhabib KF, Alhalaiqa FN, Ali A, Ali A, Ali BR, Ali MD, Ali MU, Ali R, Ali SS, Al-Iede M, Alif SM, Alipour M, Al-Jabi SW, Aljunid SM, Alkhatib MH, Alkubati SA, Allawi RH, Allemailem KS, Allouh MZ, Almagharbeh WT, Almahmeed W, Al-Marwani S, Almazan JU, Alnaeem MM, Alniss HY, Alomari MA, Alotaibi HFF, Alqahtani SA, AlQudah M, Alqudimat MR, Al-Qudimat AR, Al-Raddadi RM, Alrimawi I, Alrousan SM, Alsbou M, Alshahrani NZ, Al-Shami AS, Altaany Z, Altaf A, Althobiani MA, Altwalbeh D, Alwafi H, Al-Worafi YM, Aly H, Al-Zalabani AH, Alzoubi A, Alzoubi KH, Al-Zubairi AS, Amafah J, Mohammadi MA, Amin A, Amini S, Amini-Salehi E, Amusa GA, Ananda RA, Ancuceanu R, Ang SP, Anieto EM, Anil A, Anjana P, Anuoluwa BS, Anvari S, Anwar SL, Anyasodor AE, Appati W, Arabloo J, Arafa EA, Arafat M, Aravkin AY, Areda D, Arefnezhad R, Aregawi BB, Arias de la Torre J, Aripov T, Arockiaraj J, de Arruda GA, Asdaq SMB, Asghari-Jafarabadi M, Ashraf S, Ashraf SA, Ashraf T, Asiamah-Asare BKY, Atac O, Athar M, Athari SS, Atorkey P, Aurangzeb K, Awan SJ, Awan UA, Awol KLL, Awotidebe AW, Ayala CO, Ayli BI, Azad AKM, Azarboo A, Aziz SA, Azzam AY, Azzolino D, Babiker R, Babu AS, Babu GR, Badar M, Badiye AD, Badran AA, Baghlaf KK, Baig AA, Bakhshali MA, Balabekova M, Balakrishnan S, Baltatu OC, Banach M, Banik PC, Barqawi HJ, Barrow A, Barua L, Bashir MI, Bashir S, Bashiri A, Bastan MM, Bayat M, Bayih MT, Beeraka NM, Begum T, Behera P, Behera SM, Behnam B, Bejarano Ramirez DF, Belayneh M, Bello AB, Belo L, Berihun AA, Bhaskar S, Bhattacharjee P, Bhatti GK, Bhatti JS, Biswas A, Biswas B, Bizzozero-Peroni B, Bodur M, Bogale SK, Bohn L, Boloor A, Bolourinejad P, Bonny A, Botero Carvajal A, Bouaoud S, Boudalia S, Britton G, Bugiardini R, Busch F, Bustanji Y, Butt ZA, Campos LA, Cao Y, Catapano AL, Cegolon L, Cembranel F, Cenko E, Cerin E, Chadwick J, Chakraborty C, Chandika RM, Chandrasekar EK, Chandrasekaran B, Chattu VK, Chau LD, Chaudhary AA, Chaudhuri S, Cheema AAA, Chen AT, Chen H, Chen H, Cheng H, Cheung KC, Chew NWS, Chi G, Chichagi F, Ching PR, Cho WCS, Choi DW, Chong B, Chopra D, Chopra H, Chopra S, Choudhari SG, Chu DT, Chukwu CW, Chung SC, Chung S, Cicero AFG, Cosma C, Criqui MH, Cruz-Martins N, Dadras O, Dahabiyeh L, Dahal Khatri B, Dai X, Dai Z, Dalakoti M, D'Amico E, Damtie ET, Dandona L, Dandona R, D'Anna L, Danpanichkul P, Darcho SD, Dardas LA, Das SK, Davletov D, Davletov K, Dejenie TA, Del Bo' C, Delgado-Enciso I, Denova-Gutiérrez E, Dergaa I, Derseh HA, Derviševic E, Desale AT, Devanbu VGC, Devegowda D, Dewan SMR, Dhali A, Dhimal M, Dhungel B, Dias da Silva D, Didehvar K, Ding X, Do TC, Do THP, Dohare S, Dong D, D'Oria M, Dorostkar F, Doshi OP, Doshi RP, Dourado PMM, Dowou RK, Dresse MT, Du M, Duncan BB, Duraes AR, Ebohon O, Ebraheim LLM, Edeh C, Eftekhari B, Sedeh AE, Ekholuenetale M, El Arab RA, Eladl MA, Eldaboush A, El-Dahiyat F, Elgendy IY, Elhadi M, Elhoumed M, El-Huneidi W, Elmeligy OAA, Elmonem MA, Elmoselhi AB, Elnaem MH, Eltahawy AS, Etaee F, Fabin N, Fadaka AO, Fagbamigbe AF, Fakhradiyev IR, Fakorede S, Farasani A, Fareed M, Farhana A, Faris MEM, Farsi F, Fatima Z, Fayaz M, Fazylov T, Fekadu G, Fernandez-Jimenez R, Ferreira N, Fischer F, Fogacci F, Fonzo M, Foschi M, Gadanya MA, Gajdács M, Galali Y, Ganesan B, Ganesh B, Gangachannaiah S, Gao D, Garcia-Azorin D, Garg P, Gasevic D, Gautam RK, Gaye B, Gebresilassie MH, Getacher L, Gete KY, Ghadirian F, Ghaffari K, Ghaffari Jolfayi A, Ghamkhar A, Gharaibeh L, Ghasemi M, Ghazy RM, Ghimire S, Ghith N, Gil AU, Gilani SA, Gill PS, Gnedovskaya EV, Goh LH, Gohari K, Gohil MN, Golechha M, Goleij P, Golmohammadi M, Goulart AC, Goyal A, Grada A, Grover A, Gu L, Gubari MIM, Gufue ZH, Guha A, Gunawardane DA, Guo Z, Gupta R, Gupta S, Gurgoglione FL, Guzman-Esquivel J, Guzmán-Muñoz E, Haghtalab A, Nam NH, Hailu KT, Halder P, Hamdy NM, Hamidi H, Hamidi S, Hammad EA, Hamoudi R, Hanif A, Hanifi N, Hankey GJ, Harsini S, Hartmann P, Hasan I, Hashempur MH, Hasnain MS, Hassan A, Hassan IN, Hassan I, Hassan N, Hassan TS, Hassan Ahmed O, Hayat K, Hebert JJ, Helmy YA, Hezam K, Hiraike Y, Holla R, Hoseinzadeh M, Hostiuc M, Hostiuc S, Hotwani P, Htay MNN, Hu Y, Huang J, Huang YS, Hushmandi K, Hussein D, Hussein MA, Hwang BF, Ibitoye SE, Ibrahim IA, Ibrahim KS, Ibrayeva A, Ikiroma A, Ikram J, Ilesanmi OS, Ilic IM, Ilic MD, Imam MT, Imani M, Imodoye SO, Imoh LC, Inbaraj LR, Ionescu AI, Ionescu RT, Iqhrammullah M, Irham LM, Ishaqui AA, Islek D, Ismail NE, Ismoldayev Y, Isola G, Iwagami M, Iyer M, Izquierdo-Condoy JSS, Jacob J, Jafari-Khounigh A, Jahanshahi A, Jahrami H, Jakovljevic M, Jamal A, Jamali N, Jamaluddin J, James J, Jamshidi M, Jansen R, Jarrahi E, Javaid SS, Jawaid T, Jayasinghe YA, Jebasingh FK, Jemal M, Jeong S, Jeswani BM, Ji Z, Jibat NT, Jin W, Jokar M, Joo T, Joseph AP, Joseph MA, Joseph N, Raj JVSJM, Joshi K, Joshua CE, Jung SH, Jürisson M, K V, Kadir DHH, Kahe F, Kakkar AK, Kalani R, Kalavani K, Kalra S, Kamenova S, Kamorudeen RT, Kamyshnyi O, Kanaan SF, Kanmodi KK, Kansal S, Kantar RS, Kapoor N, Kar D, Karajizadeh M, Karakasis P, Karasneh RA, Karimi A, Karimi Behnagh A, Karun S, Kashoo FZ, Kashyap MK, Kausar MA, Kazemian S, Kebede YT, Kesse-Guyot E, Khademi R, Khader YS, Khajuria H, Khaleel A, Khalid N, Khalid S, Khalil AA, Khalili A, Khalili P, Khan A, Khan M, Khan MAS, Khan MI, Khan MAB, Khan MH, Khan S, Khan S, Khan YS, Khasbage SU, Khatatbeh MM, Kheirallah KA, Khoshvaght S, Khosla P, Khosravi S, Kim HJ, Kim K, Kimokoti RW, Kisa A, Kishore L, Kivimäki M, Kokkorakis M, Kolahi AA, Kompani F, Kondybayeva A, Korzh O, Kostev K, Koulmane Laxminarayana SL, Krishan K, Kua CH, Kuddus M, Kulimbet M, Kulkarni V, Kumar C, Kumar D, Kumar GA, Kumar J, Kumar L, Kumar N, Kumar SK, Kundu A, Kundu S, Kunutsor SK, Kurniasari MD, Kurpad KP, Kusuma D, Kytö V, Lahariya C, Lai DTC, Lai H, Lajunen T, Lakanova B, Lallukka T, Lantos T, Larebo YM, Larsson AO, Lasrado S, Le DT, Le TTT, Le T, Le TTB, Ledda C, Lee H, Lee H, Lee SW, Lee SV, Lee SW, Lee WC, Leivaditis V, Lema GK, Lemma DA, Lenjisa J, Lewis MS, Li C, Li MC, Li Q, Li S, Li X, Li Y, Lim LL, Lindholm D, Liu H, Liu X, Liu X, Liu Y, Livingstone KM, Llanaj E, Lodhi MS, Lokunarangoda NC, López-Gil JF, Lorkowski S, Lucchetti G, Lui PPY, Luo P, Lv L, Lytvyak E, M Amin HI, Ma KS, Mabrok M, Machoy-Rakoczy M, Madinehzad SA, Maffia P, Magaña Gómez JA, Mahalleh M, Mahmood NH, Malik AA, Malik MZ, Malik T, Malta DC, Mamand DR, Maniya MT, Mannethodi K, Mansoor F, Mansourian M, Manzoor S, Maqsood K, Marateb HR, Marghani BH, Marino M, Martinez-Piedra R, Martini D, Martini S, Martorell M, März W, Marzouk S, Masi S, Masrouri S, Mathur N, Matozinhos FP, Mattiello R, Maude RJ, Mavrovounis G, McPhail SM, Mehto S, Meles HN, Mendoza W, Menezes GA, Menezes RG, Mengistie EA, Menon TP, Mensah GA, Merlino G, Mestrovic T, Mettananda CDK, Mettananda S, Metwally MMM, Miao Jonasson J, Mikrajab MAN, Minhas AMK, Mirrakhimov EM, Mitra S, Mitra T, Mittal M, Modi D, Mohamed MG, Mohamed NS, Mohamed Ahmed KAH, Mohammad AM, Mohammad T, Mohammadi A, Mohammadi M, Mohammadi S, Mohammadian-Hafshejani A, Mohammed O, Mohan S, Mohsen Y, Molla TS, Molokhia M, Monazzami A, Moni MA, Montazeri Namin S, Moodi Ghalibaf A, Morovvati M, Mosaddeghi Heris R, Motappa R, Mousavi SA, Mousavi Kiasary SMS, Mozafar M, Mozahheb Yousefi K, Mubarik S, Muhammad JS, Munkhsaikhan Y, Munshi A, Musa S, Muthu S, Mwita JC, Myung W, Nabipoorashrafi S, Nagarajan AJ, Naik GR, Naik H, Nainu F, Nargus S, Nartey Y, Nasrollahizadeh A, Nassar M, Natto ZS, Nauman J, Naureen Z, Navaratna SNK, Nawaiseh HK, Nayak BP, Nayak VC, Nazari M, Ndakotsu AK, Nega AT, Nega MH, Negash AA, Negoi I, Nejad Shahrokh Abadi R, Nematollahi MH, Nguyen CD, Nguyen CT, Nguyen HTH, Nguyen NP, Nguyen PT, Nguyen VT, Niazi RK, Nieddu L, Nketia R, Nomura S, Noreen M, Nawsherwan None, Noubiap JJ, Nri-Ezedi CA, Ntsekhe M, Nugen F, Nur A, Oancea B, Odat RM, Oddi FM, Odediji SA, Ogunmodede OS, Oh IH, Ojedoyin OO, Ojo OA, Okati-Aliabad H, Okekunle AP, Okonji OC, Oliveira GMM, Olorukooba AA, Ong QC, Ordak M, Orru H, Orscelik A, Ortiz A, Ortiz-Prado E, Osborne A, Osei GN, Ostrominski JW, Osuagwu UL, Oumer A, Ouyahia A, Owolabi MO, Oyebola K, Ozsahin I, Padukudru Anand M, Padron-Monedero A, Padubidri JR, Palicz T, Panda SK, Pandi-Perumal SR, Panos GD, Papa MV, Papadimopoulos I, Pardhan S, Parija PP, Parikh RR, Pascucci E, Pasovic M, Passera R, Patel KN, Patel M, Patel NN, Patel NR, Patel S, Patil A, Patil S, Patoulias D, Pattnaik S, Pazoki Toroudi H, Pekarcikova J, Peprah P, Pereira G, Perico N, Perna S, Petermann-Rocha F, Pirera E, Pirnejad H, Plotnikov E, Poddighe D, Poluru R, Porntaveetus T, Pradhan PMS, Prasad M, Prashant A, Prates EJS, Pugliese NR, Puvvula J, Qi X, Qiu JY, Qureshi A, Radhakrishnan V, Raghav P, Raghav YSR, Raghuveer P, Rahamon SK, Rahim F, Rahim HM, Rahimi S, Rahman FM, Rahman MM, Rahman MHU, Rahman M, Rahman MA, Raj JP, Raja A, Rajendran J, Rajput P, Ramadan MM, Ramasamy C, Ramasamy SK, Rao AG, Rao M, Rao SJ, Rashedi V, Rasouli-Saravani A, Rath S, Rathi I, Rathish D, Rauniyar SK, Rawaf DL, Rawaf S, Rawassizadeh R, Ray A, Reddy MMRK, Redwan EM, Rehman NU, Remuzzi G, Rezaei M, Rezaei N, Rezaeian M, Rodriguez JAB, Roever L, Romadlon DS, Romoli M, Rony MKK, Ross AGP, Roy S, Roy S, Rubeshkumar P, Russo M, Rwegerera GM, Saad AMA, Saber-Ayad MM, Sabet CJ, Sadarangani KP, Sadat Rafiei SK, Saddique MN, Sadee BA, Sadeghi E, Sadeghi E, Sadeghi M, Sadek B, Sadek M, Sadr H, Saeb MR, Saeed M, Saeed U, Saeedi M, Safiullah M, Saghazadeh A, Sagoe D, Sah AK, Sharif-Askari FS, Sahebkar A, Sajadi SM, Sajid MR, Saki M, Sakshaug JW, Salami AA, Saleem RSZ, Saleh MA, Salehi M, Salihu AT, Salimi S, Samargandy S, Samodra YL, Samy AM, Saravanan A, Sarfo JO, Sarmadi M, Sarode GS, Sarode SC, Sarrafzadegan N, Sassano M, Sathian B, Sathya Narayanan MK, Savabi Far M, Schlaich MP, Schuermans A, Schwarz G, Sejben A, Selvaraj S, Semreen MH, Senol YC, Serban D, Sessa F, Sethi Y, Setiawan CH, Sewor C, Seylani A, Shahid S, Shahini E, Shahrahmani F, Shahwan MJ, Sham S, Shamim MA, Shamsi A, Shan D, Shanawaz M, Shannawaz M, Sharif N, Sharifan A, Sharma BK, Sharma B, Sharma K, Sharma M, Sharma RK, Sharma U, Sharma V, Shastry S, Shehzadi S, Sheidaei A, Shenoy RR, Shetty M, Shetty PH, Shi F, Shi HZ, Shi Y, Shimels T, Shiri R, Shittu A, Shiue I, Shoaib A, Shool S, Shorofi SA, Shrestha S, Shuval K, Sia CH, Siddig EE, Siddiqi AK, Siddiqua A, Silva DAS, Silva LMLR, Simkhada PP, Singh A, Singh B, Singh H, Singh H, Singh JA, Singh L, Singh P, Singh PS, Singh P, Singh S, Singh SK, Singh S, Singh V, Sinha MK, Sinha R, Skryabin VY, Sokhal BS, Sood P, Soraneh S, Sorensen RJD, Sorrentino M, Spartalis M, Srivastav P, Stachteas P, Stanikzai MH, Starodubova AV, Straube S, Stubbs P, Su CY, Subramaniyan V, Suhag A, Sulaieva O, Sulaiman SK, Suleiman Odidi M, Sulistiyorini D, Sun J, Sun Z, Swain CK, Szarpak L, Ty SS, Tabaee Damavandi P, Tabarés-Seisdedos R, Tabatabaei SM, Tabatabaeizadeh SA, Tabatabai S, Tabche C, Tadele A, Tagiisuran B, Taha Osman Ali E, Taheri Soodejani M, Taiba J, Tajabadi S, Talic S, Talukder A, Tamehri Zadeh SS, Tamiru Adugna D, Tampa M, Tan J, Tanabayeva D, Tanashat M, Tang J, Tantisattamo E, Tariku MK, Tariq S, Tavangar SM, Tedla MG, Temsah R, Teramoto M, Tesfamariam WB, Tesfu AA, Tewari J, Thakar V, Thangavelu L, Tharwat I, Tharwat S, Thienemann F, Thiruvengadam M, Thomas NK, Ticoalu JHV, Tiruye TY, Tiwari K, Tleshev M, Tomo S, Tonelli M, Topor-Madry R, Touvier M, Tovani-Palone MR, Tran AT, Tran TH, Tran Minh Duc N, Trico D, Tristan CD, Tse G, Tseriotis VS, Tualeka AR, Tye SC, Udoakang AJ, Ullah A, Ullah R, Ullah S, Umair M, Umar L, Upadhya D, Upadhyay E, Usman JS, Uzun Ozsahin D, Uzunçibuk H, Vaithinathan AG, Vakili O, Van den Eynde J, Varghese J, Vasankari TJ, Vellingiri B, Venketasubramanian N, Verma AK, Verma P, Villalobos-Daniel VE, Vlassov V, Wan JY, Wang C, Wang N, Wang Q, Wang S, Wang S, Wang W, Wang W, Wang W, Wang Y, Wang Y, Wang Z, Wani TAA, Waqar AB, Wei MY, Weintraub RG, Wibowo YC, Wicaksana AL, Wickramasinghe DP, Wickramasinghe ND, Wilandika A, Witts WK, Wonde TE, Wongsin U, Wu P, Xiao G, Xie W, Xu S, Xu S, Xu W, Xu X, Yadav V, Yadegar A, Yahoo S, Yamagishi K, Yang H, Yano Y, Yao H, Yarahmadi A, Yaribeygi H, Yesuf SA, Yin D, Yismaw YE, Yon DK, Yonemoto N, Yu C, Yu EA, Yu H, Yu Y, Yuan Q, Yuzbashian E, Zafar M, Zaghampour M, Zamagni G, Zamora N, Zanghì A, Zargar S, Zawiah M, Zeariya MGM, Zeru EM, Zhang B, Zhang CJP, Zhang H, Zhang JMF, Zhang Y, Zhang Z, Zhanuzakov M, Zhao Z, Zheng MH, Zhong A, Zhong CC, Zhou H, Zhou J, Zhou XD, Zhu Z, Zhumagaliuly A, Zitoun OA, Zoghi G, Zoromba MA, Zumla A, Zyoud AH, Zyoud SH, Zyoud SH, Hay SI, Mokdad AH, Murray CJL, Roth GA.
Global Burden of Elevated LDL-C: Findings From the Global Burden of Disease Study 2023.
JAMA 2026-07-29 doi: 10.1001/jama.2026.8628 PMID: 42525403

11: Lee K, Negi H, Chen X, Atallah-Yunes K, Truslow S, Castelino RE, Guest MR, Ciancone AM, Lu X, Tarasov SG, Chari R, Walters KJ, O'Reilly FJ.
Structures of dynamic interactors at native proteasomes by PhIX-MS and cryo-electron microscopy.
Molecular cell 2026-07-21 doi: 10.1016/j.molcel.2026.06.032 PMID: 42476128

12: Yao Y, Harrison CB, Freddolino L, Schulten K, Mayer ML.
Author Correction: Molecular mechanism of ligand recognition by NR3 subtype glutamate receptors.
The EMBO journal 2026-07-17 doi: 10.1038/s44318-026-00861-6 PMID: 42463914

13: Kautz A, Yang DH, Chickery S, Irving SA, Klein NP, Grannis SJ, Ong TC, Ball SW, DeSilva MB, Dascomb K, Naleway AL, Zerbo O, Hansen JR, Block L, Dixon BE, Rogerson CM, Fadel WF, Duszynski TJ, Barron MA, Mayer D, Chavez C, Zhuang Y, Weber ZA, Vazquez-Benitez G, Cao J, Akinsete OO, Bride D, Sheffield T, Van Otterloo J, Arndorfer J, Natarajan K, Ciesla AA, Najdowski M, Mak J, DeCuir J, Wiegand RE, Link-Gelles R, Payne AB.
Influence of correlated vaccination behaviors on estimates of COVID-19 vaccine effectiveness in older adults - VISION network, October 2023 - March 2024.
Vaccine 2026-07-02 doi: 10.1016/j.vaccine.2026.128891 PMID: 42391690

14: Wiegand RE, Payne AB, Mak J, Chickery S, Reese SE, Klein NP, Grannis SJ, Ong TC, Rowley EAK, DeSilva M, Dascomb K, Irving SA, Zerbo O, Hansen JR, Block L, Jacobson KB, Dixon BE, Rogerson CM, Duszynski TJ, Fadel WF, Barron MA, Mayer D, Chavez C, Yang DH, Ball SW, McEvoy CE, Akinsete OO, Sheffield T, Bride D, Arndorfer J, Van Otterloo J, Naleway AL, Natarajan K, Najdowski M, Ciesla AA, Kautz A, DeCuir J, Link-Gelles R.
Estimated Effectiveness of 2024-2025 COVID-19 Vaccines in Adults.
JAMA internal medicine 2026-06-15 doi: 10.1001/jamainternmed.2026.1936 PMID: 42295789

15: Zhang L, Tisserand G, Shen Y, Salehi M, Amar L, Cui Y, Świątkowska-Stodulska R, Moog S, Liu J, Gubbi S, Falhammar H, Kocjan T, Igaz P, Hadoux J, Young WF, Remde H, Babińska A, Miguel V, Beuschlein F, Liu L, Palmieri S, Jiang J, Fischer A, Varghese J, Carreira A, Parasiliti-Caprino M, Nölting S, Zhou Y, Prodanov T, Bancos I, Fassnacht M, Jimenez C, Alkaissi H, Tong A, Pacak K, Crona J.
Safety of biopsy in phaeochromocytoma and paraganglioma: an international, multicentre, retrospective cohort study.
The lancet. Diabetes & endocrinology 2026-05-12 doi: 10.1016/S2213-8587(26)00033-1 PMID: 42114537

16: Andricioaei I, Best RB, Birge RR, Boresch S, Brunger AT, Brooks BR, Buck M, Brüschweiler R, Caflisch A, Case DA, Cui Q, Dejaegere A, Dinner AR, Elber R, Evanseck JD, Gao J, Guo H, Hubbard RE, Kuriyan J, Joseph-McCarthy D, Levy RM, Nilsson L, Mattos C, MacKerell AD, McCammon JA, Michnick SW, Mulholland A, Meuwly M, Pastor RW, Reuter N, Roux B, Sali A, Schlick T, Smith JC, Stote RH, Straub JE, Taly A, van der Vaart A, Wan S, Weiss MA, Yang W, York DM, Zhou Y.
The scientific legacy of Martin Karplus from the perspective of his collaborators.
Biophysical journal 2026-04-03 doi: 10.1016/j.bpj.2026.03.050 PMID: 41928473

17: Mann DL, Chirinos JA, Yu J, Yang W, McNamara DM, Richards B, Taddei-Peters WC, Jeffries N, Stewart GC, Qian C, Cappola TP, Aaronson KD, None None.
Circulating Proteomic Profiles in Ambulatory Patients With Advanced Stage C2D Heart Failure: Insights From the Registry Evaluation of Vital Information for VADs in Ambulatory Life (REVIVAL) Registry.
Journal of cardiac failure 2026-01-25 doi: 10.1016/j.cardfail.2026.01.006 PMID: 41580271

18: Kim H, Issara-Amphorn J, Yoon SH, Banerjee A, Nita-Lazar A.
Proteome-Wide Analysis of Palmitoylated Proteins in Macrophages Reveals Novel Insights Into Early Immune Signaling.
Proteomics 2025-12-29 doi: 10.1002/pmic.70100 PMID: 41457686


RECENT TOPICS IN THE LITERATURE:


METHODS — Sample Preparation Tips


N. Premaraj et al., "Advancing cryo-EM and cryo-ET through innovation in sample carriers: a perspective" PMID: 40476672.
I.J. Hirst et al., "Untangling the effects of flexibility and the AWI in cryoEM sample preparation: A case study using KtrA" PMID: 40324569.
Y. Huang et al., "Recent Advances in Expression Screening and Sample Evaluation for Structural Studies of Membrane Proteins" PMID: 39362625.
K. McGuire et al., "Tuning ice thickness using the chameleon for high-quality cryoEM data collection" PMID: 38746094.
B. Cook et al., "Preparation of oxygen-sensitive proteins for high-resolution cryoEM structure determination using (an)aerobic blot-free vitrification" PMID: 39091810.
R. Warmack et al., "Anaerobic cryoEM protocols for air- sensitive nitrogenase proteins" PMID: 38575747.
I.J. Hirst et al., "CryoEM grid preparation: a closer look at advancements and impact of preparation mode and new approaches" PMID: 38864435.
S. Yadav and K.R. Vinothkumar, "Factors affecting macromolecule orientations in thin films formed in cryo-EM" PMID: 38935342.
S.E.J. Bowman et al., "Preparing research samples for safe arrival at centers and facilities: recipes for successful experiments" PMID: 38990054.

METHODS — Macromolecular Crystallography


N. L. Inniss et al., "Structural genomics of bacterial drug targets: application of a high-throughput pipeline to solve 59 protein structures from pathogenic and related bacteria" PMID: 40391899.
.J. Simpkin et al. "Slice'N'Dice: maximizing the value of predicted models for structural biologists" PMID: 39976565.
G. Budziszewski et al. "Preparing for successful protein crystallization experiments" PMID: 40454464.
M. Schaefer et al., "Surface-mutagenesis strategies to enable structural biology crystallization platforms" PMID: 39207897.

METHODS — Integrative Structural Biology


S. Bazzi and S. Sayyed, "Revealing arginine-cysteine and glycine-cysteine NOS linkages by a systematic re-evaluation of protein structures" PMID: 40360719.
R. Mitra et al. "RNAproDB: a webserver and interactive database for analyzing protein-RNA interactions" PMID: 40126909.
H. McCann et al., "R2DT: a comprehensive platform for visualizing RNA secondary structure" PMID: 39921562.
B. Vallat et al., "PDB-IHM: a system for deposition, curation, validation, and dissemination of integrative structures" PMID: 40110969.
D. A. Erlanson et al., "Where and how to house big data on small fragments" PMID: 40325009.
M. Bazayeva et al., "A database overview of metal-coordination distances in metalloproteins" PMID: 38682667.
H. Zheng et al., "PinMyMetal: a hybrid learning system to accurately model metal binding sites in macromolecules" PMID: 40155596.
M. Bochtler, "X-rays, electrons, and neutrons as probes of atomic matter" PMID: 38412856.

METHODS — XFEL, Serial Crystallography


L. Sauthof et al. "Serial-femtosecond crystallography reveals how a phytochrome variant couples chromophore and protein structural changes" PMID: 40435264.
M. Maestre-Reyna et al., "Capturing structural intermediates in an animal-like cryptochrome photoreceptor by time-resolved crystallography" PMID: 40378212.
M. Sonawal et al. "Functional implications of hexameric dynamics in SARS-CoV-2 Nsp15" PMID: 40411374.

METHODS — Micro-ED


M.T.B. Clabbers and T. Gonen, "Recovering high-resolution information using energy filtering in MicroED" PMID: 40370641.
J. Lin et al., "Ligand screening and discovery using cocktail soaking and automated MicroED" PMID: 40027750.
W. J. Nicolas et al., "Structure of the lens MP20 mediated adhesive junction" PMID: 40140346.
J.E. Miller et al., "AlphaFold-assisted structure determination of a bacterial protein of unknown function using X-ray and electron crystallography" PMID: 38451205.

METHODS — Cryo-EM


R.C. Kretsch et al., "Complex water networks visualized by cryogenic electron microscopy of RNA" PMID: 40068818.
R.C. Kretsch et al., "Naturally ornate RNA-only complexes revealed by cryo-EM" PMID: 40328315.
G. Pintilie et al., "Q-score as a reliability measure for protein, nucleic acid, and small molecule atomic coordinate models derived from 3DEM density maps" PMID: 39868161.
R. Read et al., "Likelihood-based interactive local docking into cryo-EM maps in ChimeraX" PMID: 39058381.
R. Karimi et al., "Vesicle Picker: a tool for efficient identification of membrane protein complexes in vesicles" PMID: 39481498.
D. Bobe et al., "Multi-species cryoEM calibration and workflow verification standard" PMID: 39494502.
C.L. Lawson et al., "Outcomes of the EMDataResource Cryo-EM Ligand Modeling Challenge" PMID: 38343795.
B. Greber et al., "High-resolution cryo-EM of the human CDK-activating kinase for structure-based drug design" PMID: 38480681.
G.J. Kleywegt, "Community recommendations on cryoEM data archiving and validation" PMID: 38358351.
M. Kschonsak et al., "Cryo-EM reveals an unprecedented binding site for Nav1.7 inhibitors enabling rational design of potent hybrid inhibitors" PMID: 36975198.

METHODS — SAXS


E. Brookes et al., "SAXS-A-Fold: a website for fast ensemble modeling optimizing the fit of AlphaFold or user-supplied protein structures with flexible regions to SAXS data" PMID: 40475948.
K. Lytje and J.S. Pederson, "Validation of electron-microscopy maps using solution small-angle X-ray scattering" PMID: 38935344.

METHODS — NMR Spectroscopy


L. S. Pidgu et al., "Observing nucleotide flipping in DNA using indirect 2’-F nucleotide probes and 19F NMR" PMID: 40488280.
M. Bütikofer et al., "Rapid Protein-Ligand Affinity Determination by Photoinduced Hyperpolarized NMR" PMID: 38957136.

METHODS — AlphaFold


A. Fadini et al., "AlphaFold as a prior: experimental structure determination conditioned on a pretrained neural network" PMID: 40027838.
R.M. Keegan et al., "The success rate of processed predicted models in molecular replacement: implication for experimental phasing in the AlphaFold era" PMID: 39360967.
B.K. Poon et al., "The Phenix-AlphaFold webservice: enabling AlphaFold predictions for use in Phenix" PMID: 3864706.
A.M. Lau et al., "Exploring structural diversity across the protein universe with The Encyclopedia of Domains" PMID: 39480926.
J. Abramson et al., "Accurate structure prediction of biomolecular interactions with AlphaFold 3" PMID: 38718835.

METHODS — Mass Spectrometry


M.A. Gonzalez-Lozano et al., "EndoMAP.v1 charts the structural landscape of human early endosome complexes" PMID: 40437099.
R.A. D'Ippoito et al., "Determining KRAS4B-Targeting Compound Specificity by Top-Down Mass Spectrometry" PMID: 39052227.
A. Vetrano et al., "Protein secondary structure patterns in short-range cross-link atlas" PMID: 4043759.
M.D. Mann et al., "Structural proteomics defines a sequential priming mechanism for the progesterone receptor" PMID: 403555435.

READINGS & TUTORIALS — General Structural Biology


R. Nussinov et al., "Allostery in disease: anticancer drugs, pockets, and the tumor heterogeneity challenge" PMID: 40021049.
K. Matange et al., "Biological polymers: evolution, function, and significance" PMID: 39905926.
L.C. Schofield et al., "Post-translational modifications in the Protein Data Bank" PMID: 39207896.

READINGS & TUTORIALS — Macromolecular Crystallography


K.L. Shelley and E.F. Garman, "Identifying and avoiding radiation damage in macromolecular crystallography" PMID: 38700059.
G. Khusainov et al., "The time revolution in macromolecular crystallography" PMID: 38616866.
J.R. Helliwell et al., "The evolution of raw data archiving and the growth of its importance in crystallography" PMID: 38864497.
D.J. Haas, "Fifty years on: why macromolecular cryocrystallography has been so successful" IUCr Newsletter (2023) 31(3).
W.A. Hendrickson, "Facing the phase problem" PMID: 37668214.

READINGS & TUTORIALS — Cryo-EM


C.T. Chien et al., "Single-particle cryogenic electron microscopy structure determination for membrane proteins" PMID: 40228430.
G.C. Lander, "Single particle cryo-EM map and model validation: It's not crystal clear" PMID: 39293191.
E. Nogales & J. Mahamid, "Bridging structural and cell biology with cryo-electron microscopy" PMID: 38570716.

READINGS & TUTORIALS — Serial Crystallography


C. J. Tremlett et al., "Small but mighty: the power of microcrystals in structural biology" PMID: 40080159.
A. Henkel and D. Oberthur, "A snapshot love story: what serial crystallography has done for us" PMID: 38984902.

READINGS & TUTORIALS — MicroED


A. Haymaker & B.L. Nannenga, "Advances and applications of microcrystal electron diffraction (MicroED)" PMID: 10882645.

READINGS & TUTORIALS — NMR Spectroscopy


O. A. Alimowska et al., "Advances in the application of NMR to the study of GPCRs and ligand-GPCR interactions" PMID: 40485639.
G. Platzer et al., "NMR-driven structure-based drug discovery by unveiling molecular interactions" PMID: 40450181.

READINGS & TUTORIALS — Atomic Force Microscopy (AFM)


Y. Jiang et al., "A structural biology compatible file format for atomic force microscopy" PMID: 39955301.
A.C. Dumitru et al., "Recent advances in the application of atomic force microscopy to structural biology" PMID: 37044358.

READINGS & TUTORIALS — AlphaFold/AI


E. Callaway, "Chemistry Nobel goes to developers of AlphaFold AI that predicts protein structures" PMID: 39384918.
E. Callaway, "The huge protein database that spawned AlphaFold and biology's AI revolution" PMID: 39424937.
T.C. Terwilliger et al., "AlphaFold predictions are valuable hypotheses and accelerate but do not replace experimental structure determination" PMID: 38036854.
S. Subramaniam, "Structural biology in the age of AI" PMID: 38066345.

READINGS & TUTORIALS — Protein Data Bank/Data Archiving


H. Berman and S.K. Burley, "Protein Data Bank (PDB): Fifty-three years young and having a transformative impact on science and society" PMID: 39973356.
S.K. Burley et al., "Updated resources for exploring experimentally-determined PDB structures and computed structure models at the RCSB Protein Data Bank" PMID: 39607707.

IN THE NEWS:


Ruth Nussinov elected to the National Academy of Sciences, 05/02/2025
Simulations implicate structural changes as a culprit in mutant protein’s cancer role and point to possible treatments, 03/25/2025
Lipoprotein structure gives insights into "bad" cholesterol, 01/14/2025

DATABASES — Structural Biology


AlphaFold DB
BioCyc
DisProt
ExPASy
HAD
HIC-Up
NDB
PDB
PDBe
PDB SARS-CoV-2 Resources
SARS-CoV-2 Related Structures
RaMP-DB
virusMED

UPCOMING MEETINGS, CONFERENCES, & WORKSHOPS


75th ACA Annual Meeting, July 18-23, 2025 Lombard, IL
Microscopy Society of America Annual Meeting, July 27-31, 2025 Salt Lake City, UT
Cold Spring Harbor Laboratory Macromolecular Crystallography Course, October 12-28, 2025 Cold Spring Harbor, NY Application Deadline: July 15, 2025