Mission Statement

 

 

 

The overall mission of the Oncogenomics section of the Genetics Branch is to leverage the power of genome wide high-throughput approaches to improve the outcome of patients with high risk cancers, with a focus on neuroblastoma, rhabdomyosarcoma, and Ewing’s sarcoma.

Research Goals of the Oncogenomics Section of the Genetics Branch

1.  Applying high throughput genomics and proteomics to characterize high risk pediatric malignancies.

2.  Identification of novel diagnostic and prognostic biomarkers and targets, validation of novel targets and translation to the clinic.

3.  Systems Biology and data integration to decipher the complex interactions of DNA copy number, DNA mutations, messenger RNA (mRNA), micro RNA (miRNA) and protein with the cancer phenotype.

4.  Public release of data to stimulate collaborative research and maximally utilize high quality data generated by our section and other investigators in the field.

5.  Technology Development

6.  Translation of our findings to the clinic

To achieve these goals we are applying high throughput technologies including:

  • Next generation sequencing (whole genome, whole exome, transcriptome and ChIp-Seq)
  • Small RNA technologies.
  • Isotope-Coded Affinity Tags (ICAT)
  • Small molecule compound screening