Selected Publications

 

 

 

 

1.    Khan, J., Broadbent, V.A. (1993). Tumour lysis syndrome complicating treatment of widespread metastatic abdominal rhabdomyosarcoma.

Paediatric Haematology and Oncology. 10:151.

 

2.    Khan, J., Parsa, N.Z., Harada, T., Meltzer, P.S. and Carter N. (1998). Detection of Gains and Losses in 18 Meningiomas by Comparative Genomic Hybridization

Cancer Genetics Cytogenetics. 102: 1-5.

 

3.    Khan, J., Simon, R., Bittner, M., Chen, Y., Leighton, S.B., Pohida, T., Smith, P.D., Jiang, Y., Gooden, G.C., Trent, T.M. and  Meltzer PS. (1998). Gene Expression Profiling of Alveolar Rhabdomyosarcoma with cDNA Microarrays

Cancer Research 58, 5009-5013.

 

4.    Khan, J., Bittner, M.L, Saal, L.H, Azorsa, D.A., Teichman, U., Pavan, W., Trent, J.M., Meltzer, P.S. (1999). cDNA microarrays detect activation of a myogenic transcription program by the Pax3-FKHR fusion oncogene.

PNAS 96, 23, 13264-13269.

 

5.    Heiskanen, M.A., Bittner, M.L., Chen, Y, Khan, J., Adler, K. E., Trent, J.M. and Meltzer PS. (2000). Detection of Gene Amplification by Genomic Hybridization to cDNA Microarrays.

Cancer Research 60, 799-802.

 

6.    Dupont, J., Khan, J., Qu, B.H., Meltzer, P., Helman., L. LeRoith, D. (2001). Insulin and IGF-1 Induce Different Patterns of Gene Expression in Mouse Fibroblast NIH-3T3 Cells: Identification by cDNA Microarray Analysis.

Endocrinology 142(11): 1512-9

 

7.    Khanna, C., Khan, J., Nguyen, P., Prehn, J., Caylor, J., Yeung, C., Trepel, J., Meltzer, P., and Helman, L. (2001). Metastasis Associated Differences in Gene Expression in a Murine Model Osteosarcoma .Cancer Research 61, 3750-9.

 

8.    Javed Khan, Jun S. Wei, Markus Ringnér, Lao H. Saal,  Marc Ladanyi, Frank Westermann , Frank Berthold, Manfred Schwab, Cristina R. Antonescu, Carsten Peterson, and Paul S. Meltzer. (2001). Classification and Diagnostic Prediction of Cancers using Gene Expression Profiling and Artificial Neural Networks

Nature Medicine. Vol. 7,6; 673-679

 

9.    Dickens DS, Kozielski R, Khan J, Forus A, Cripe TP. (2002). Cyclooxygenase-2 Expression in Pediatric Sarcomas.

Pediatr Dev Pathol May 24;5(4)

 

10. Rice AM, Currier MA, Adams LC, Bharatan NS, Collins MH, Snyder JD, Khan J, Cripe TP.(2002). Ewing sarcoma family of tumors express adenovirus receptors and are susceptible to adenovirus-mediated oncolysis.

J Pediatr Hematol Oncol Oct;24(7):527-33

 

11. Zuyi Wang, Yue Wang, Jianping Lu, Sun-Yuan Kung, Junying Zhan1, Richard Lee, Jianhua Xua1, Javed Khan and Robert Clarke (2003) Discriminatory Mining of Gene Expression Microarray Data. Journal of VLSI Signal Processing System. 35;3 Pages: 255 - 272

 

12. Bomprezzi R, Ringner M, Kim S, Bittner ML, Khan J, Chen Y, Elkahloun A, Yu A, Bielekova B, Meltzer PS, Martin R, McFarland HF, Trent JM (2003). Gene expression profile in multiple sclerosis patients and healthy controls: identifying pathways relevant to disease.

Hum Mol Genet. Sep 1;12(17):2191-9.

 

13. Yu Y,  Khan J,  Khanna C, Helman L, Meltzer PS, Merlino G. (2004). Discriminatory Expression profiling identifies the cytoskeletal organizer ezrin and the developmental homeoprotein Six-1 as key metastatic regulators. (Equal first author).

Nature Medicine  2004 Jan 4, Vol. 10(2):175-81

 

14. Richard Despar, Javed Khan, and Alejandro Schaffer (2004). Tumor Classification Using Phylogenetic Methods on Expression Data.  J Theor Biol. Jun 21;228(4):477-96.

 

15. Richard D Williams, Sandra Hing, Braden T Greer, Craig C Whiteford, Jun S Wei, Rachael Natrajan, Anna Kelsey, Simon Rogers, Colin Campbell, Kathy Pritchard-Jones and Javed Khan. (2004). Prognostic Classification of Relapsing Favourable Histology Wilms Tumour using cDNA Microarray Expression Profiling and Support Vector Machines. Genes Chromosomes and Cancer. Sep;41(1):65-79.

 

16. Jun S. Wei, Braden T. Greer, Frank Westermann, Seth M. Steinberg, Chang-Gue Son, Qing-Rong Chen, Craig C. Whiteford, Sven Bilke, Alexei L. Krasnoselsky, Nicola Cenacchi, Daniel Catchpoole, Frank Berthold, Manfred Schwab, and Javed Khan (2004). Prediction of clinical outcome using gene expression profiling and artificial neural networks for patients with neuroblastoma.

Cancer Research Oct 1, 2004; 64(19).

 

17. Chen QR, Bilke S, Wei JS,Whiteford CC, Cenacchi N, Krasnoselsky AL, Greer BT, Son C, Westermann F, Berthold F, Schwab M, Catchpoole D, Khan J. (2004). cDNA array-CGH profiling identifies genomic alterations specific to stage and MYCN-amplification in neuroblastoma. BMC Genomics, 5:70

 

18. Sven Bilke, Qing-Rong Chen, Craig C. Whiteford, Javed Khan. (2005). Detection of low level genomic alterations by comparative genomic hybridization based on cDNA micro-arrays. Bioinformatics 21 (7): 1138-1145 Apr 1

 

19. Alexei L. Krasnoselsky, Craig C. Whiteford, Jun S. Wei, Sven Bilke, Frank Westermann, Qing-Rong Chen, and Javed Khan (2005). Prognostic Classification of Relapsing Altered expression of cell cycle genes distinguishes aggressive neuroblastoma

Oncogene. Feb 24;24(9):1533-41..

 

20. Chang Gue Son, Sven Bilke, Sean Davis, Braden T. Greer, Jun S. Wei, Craig C. Whiteford, Qing-Rong Chen, Nicola Cenacchi, and Javed Khan (2005). Database of mRNA Gene Expression Profiles of Multiple Human Organs

Genome Res 15 (3): 443-450 Mar

 

21. Kim HS, Choi EH, Khan J, Roilides E, Francesconi A, Kasai M, Sein T, Schaufele RL, Sakurai K, Son CG, Greer BT, Chanock S, Lyman CA, Walsh TJ. (2005). Expression of genes encoding innate host defense molecules in normal human monocytes in response to Candida albicans.

Infect Immun. Jun;73(6):3714-24.

 

22. Jun S. Wei, Craig C. Whiteford, Nicola Cenacchi, Chang Gue Son, and Javed Khan.(2005). BBC3 Mediates Fenretinide-Induced Cell Death in Neuroblastoma.

Oncogene. 2005 Aug 8

 

23. Amir A. Jazaeri, Christopher S. Awtrey, Gadisetti V. R., Chandramouli, Yao Eric Chuang, Javed Khan, Christos Sotiriou, Olga Aprelikova, Cindy J. Yee, Kristin K. Zorn, Michael J. Birrer, J. Carl Barrett, and Jeff Boyd. (2005) Gene Expression Profiles Associated with Response to Chemotherapy in Epithelial Ovarian Cancers.

Clin Cancer Res. 2005 Sep 1;11(17):6300-10

 

24. Sven Bilke, Qing-Rong Chen, Frank Westerman, Manfred Schwab, Daniel Catchpoole, and Javed Khan (2005) Inferring a Tumor Progression Model for Neuroblastoma From Genomic Data Journal of Clinical Oncology Oct; 23:7322-31

 

25. Henrich KO, Fischer M, Mertens D, Benner A, Wiedemeyer R, Brors B, Oberthuer A, Berthold F, Wei JS, Khan J, Schwab M, Westermann F. (2006) Reduced expression of CAMTA1 correlates with adverse outcome in neuroblastoma patients.

Clin Cancer Res. 2006 Jan 1;12(1):131-8.

 

26. Qingrong Chen, Sven Bilke, Jun S. Wei, Braden T. Greer, Seth M. Steinberg, Frank Westermann, Manfred Schwab, and Javed Khan (2006) Increased WSB1 Copy Number Correlates with its Over-expression which Associates with Increased Survival in Neuroblastoma. Genes Chromosomes Cancer. 2006 Sep;45(9):856-62.

 

27. Houghton PJ, Morton CL, Tucker C, Payne D, Favours E, Cole C, Gorlick R, Kolb EA, Zhang W, Lock R, Carol H, Tajbakhsh M, Reynolds CP, Maris JM, Courtright J, Keir ST, Friedman HS, Stopford C, Zeidner J, Wu J, Liu T, Billups CA, Khan J, Ansher S, Zhang J, Smith MA (2007). The pediatric preclinical testing program: Description of models and early testing results. Pediatr Blood Cancer. 2007 Dec;49(7):928-40.

 

28. Craig C. Whiteford, Sven Bilke, Braden T. Greer, Qingrong Chen, Till A. Braunschweig, Nicola Cenacchi, Jun S. Wei, Malcolm A. Smith, Peter Houghton, Christopher Morton, C. Patrick  Reynolds, Richard Lock, Richard Gorlick, Chand Khanna, Carol J. Thiele, Mikiko Takikita, Daniel Catchpoole, Stephen M. Hewitt and Javed Khan (2007). Credentialing Preclinical Pediatric Xenograft Models Using Gene Expression and Tissue Microarray Analysis. Cancer Res. 2007 Jan 1;67(1):32-40.

 

29. Qing-Rong Chen, Gordon Vansant, Kahuku Oades, Maria Pickerin, Jun S. Wei, Young K. Song, Joseph Monforte and Javed Khan (2007) Diagnosis of the Small Round Blue Cell Tumors using Multiplex PCR. J Mol Diagn. 2007, 9:80-88.

 

30. Jin Zheng, M. Eric Kohler, Qingrong Chen, James Weber, Javed Khan, Bryon D Johnson, Rimas J Orentas (2007) Serum from mice immunized in the context of Treg inhibition identifies DEK as a neuroblastoma tumor antigen. BMC Immunology, 8:4 (30 March 2007)

 

31. Jianhua Xuan, YueWang, Yibin Dong, Yuanjian Feng, BinWang, Javed Khan, Maria Bakay, Zuyi Wang,,  Lauren Pachman, SaraWinokur, Yi-Wen Chen, Robert Clarke, and Eric Hoffman (2007) Gene Selection for Multiclass Prediction by Weighted Fisher Criterion. EURASIP Journal on Bioinformatics and Systems Biolog. Volume 2007, Article ID 64628,

 

32. FrankWestermann, Kai-Oliver Henrich, Jun S.Wei, Werner Lutz, Matthias Fischer,  Rainer Koinig,  Ruprecht Wiedemeyer, Volker Ehemann,  Benedikt Brors,  Karen Ernestus,  Ivo Leuschner,  Axel Benner,  Javed Khan,  and Manfred Schwab (2007). High Skp2 Expression Characterizes High-Risk Neuroblastomas Independent of MYCN Status. Clinical Cancer Research Aug 15;13(16):4695-703. Epub 2007 Jul 25.

 

33. Catchpoole D, Lail A, Guo D, Chen QR, Khan J. (2007). Gene expression profiles that segregate patients with childhood acute lymphoblastic leukaemia: An independent validation study identifies that endoglin associates with patient outcome. Leuk Res. 2007 Dec;31(12):1741-7. Epub 2007 Jun 18.

 

34. Geoffrey Neale, Xiaoping Su, Christopher L. Morton, Doris Phelps, Richard Gorlic, Richard Lock, C. Patrick Reynolds, John M. Maris, Henry S. Friedman, Jeffrey Dome, Joseph Khoury, Timothy J. Triche, Robert C. Seeger, Richard Gilbertson, Javed Khan, Malcolm A. Smith, Peter J. Houghton (2008). Molecular Characterization of the Pediatric Preclinical Testing Panel. Clinical Cancer Research 2008 Jul 15;14(14):4572-83

 

35. J S Wei, Y K Song, S Durinck, Q-R Chen, A T C Cheuk, P Tsang, Q Zhang, C J Thiele, A Slack, J Shohet and J Khan (2008). The MYCN oncogene is a direct target of miR-34a. Oncogene. . 2008 Sep 4;27(39):5204-13. Epub 2008 May 26

 

36. Kowalska A, Brunner B, Bozsaky E, Chen QR, Stock C, Lörch T, Khan J, Ambros PF (2008). Sequence based high resolution chromosomal CGH. Cytogenet Genome Res. 121(1):1-6. Epub 2008 May 7.

 

37. Sven Bilke, Qing-Rong Chen, Jun S. Wei, and Javed Khan (2008). Whole Chromosome alterations predict survival in high risk neuroblastoma without MYCN amplification. Clinical Cancer Research. 2008 Sep 1;14(17):5540-7

 

38. Qing-Rong Chen, Young K. Song, Jun S. Wei, Sven Bilke, Shahab Asgharzadeh, Robert C. Seeger and Javed Khan (2008). An Integrated Cross-Platform Prognosis Study on Neuroblastoma Patients. Genomics. 2008 Oct;92(4):195-203. Epub 2008 Jul 30.

 

39. Alabran JL, Cheuk A, Liby K, Sporn M, Khan J, Letterio J, Leskov KS (2008). Human neuroblastoma cells rapidly enter cell cycle arrest and apoptosis following exposure to C-28 derivatives of the synthetic triterpenoid CDDO. Cancer Biol Ther. 2008 May;7(5):709-17. Epub 2008 May 7

 

40. Koichi Nishijo, Qing-Rong Chen, Lei Zhang, Amanda T. McCleish, Andrea Rodriguez, Min Jung Cho, Suresh I. Prajapati, Jonathan A. L. Gelfond, Gary B. Chisholm, Joel E. Michalek, Bruce J. Aronow, Frederic G. Barr, R. Lor Randall, Marc Ladanyi, Stephen J. Qualman, Brian P. Rubin, Robin D. LeGallo, Chiayeng Wang, Javed Khan, Charles Keller (2009).  Credentialing a Preclinical Mouse Model of Alveolar Rhabdomyosarcoma. Cancer Res. 2009 Apr 1;69(7):2902-11.

 

41. Ambros PF, Ambros IM, Brodeur GM, Haber M, Khan J, Nakagawara A, Schleiermacher G, Speleman F, Spitz R, London WB, Cohn SL, Pearson AD, Maris JM. (2009).  International consensus for neuroblastoma molecular diagnostics: report from the International Neuroblastoma Risk Group (INRG) Biology Committee. Br J Cancer. 2009 May 5;100(9):1471-82.

 

42. Vasudevan SA, Shang X, Chang S, Ge N, Diaz-Miron JL, Russell HV, Hicks MJ, Ludwig AD, Wesson CL, Burlingame SM, Kim ES, Khan J, Yang J, Nuchtern JG. (2009) Neuroblastoma-derived secretory protein is a novel secreted factor overexpressed in neuroblastoma. Mol Cancer Ther. 2009 Aug;8(8):2478-89. Epub 2009 Aug 11.

 

43. Wei JS, Johansson P, Chen QR, Song YK, Durinck S, Wen X, Cheuk AT, Smith MA, Houghton P, Morton C, Khan J.(2009) microRNA profiling identifies cancer-specific and prognostic signatures in pediatric malignancies. Clin Cancer Res. 2009 Sep 1;15(17):5560-8. Epub 2009 Aug 25.

 

44. Taylor JG 6th, Cheuk AT, Tsang PS, Chung JY, Song YK, Desai K, Yu Y, Chen QR, Shah K, Youngblood V, Fang J, Kim SY, Yeung C, Helman LJ, Mendoza A, Ngo V, Staudt LM, Wei JS, Khanna C, Catchpoole D, Qualman SJ, Hewitt SM, Merlino G, Chanock SJ, Khan J. (2009) Identification of FGFR4-activating mutations in human rhabdomyosarcomas that promote metastasis in xenotransplanted models. J Clin Invest. 2009 Nov;119(11):3395-407. doi: 10.1172/JCI39703. Epub 2009 Oct 5.

 

45. Gheeya JS, Chen QR, Benjamin CD, Cheuk AT, Tsang P, Chung JY, Metaferia BB, Badgett TC, Johansson P, Wei JS, Hewitt SM, Khan J. (2009) Screening a panel of drugs with diverse mechanisms of action yields potential therapeutic agents against neuroblastoma. Cancer Biol Ther. 2009 Dec 27;8(24).

 

46. Chen QR, Song YK, Yu LR, Wei JS, Chung JY, Hewitt SM, Veenstra TD, Khan J. (2010) Global genomic and proteomic analysis identifies biological pathways related to high-risk neuroblastoma. J Proteome Res. 2010 Jan;9(1):373-82.

 

47. Jinesh Gheeya, Peter Johansson, Qing-Rong Chen, Thomas Dexheimer, Belhu Metaferia, Young K. Song, Jun S. Wei, Jianbin He, Yves Pommier, and Javed Khan (2010) Expression Profiling Identifies Epoxy Anthraquinone Derivative as a DNA Topoisomerase Inhibitor. Cancer Lett. 2010 Jul 1;293(1):124-31. Epub 2010 Feb 4.

 

48. Chen QR, Yu LR, Tsang P, Wei JS, Song YK, Cheuk A, Chung JY, Hewitt SM, Veenstra TD, Khan J. (2010) Systematic Proteome Analysis Identifies Transcription Factor YY1 as a Direct Target of miR-34a.  J Proteome Res. 2010 Dec 23. [Epub ahead of print]

 

49. Metaferia BB, Rittler M, Gheeya JS, Lee A, Hempel H, Plaza A, Stetler-Stevenson WG, Bewley CA, Khan J (2010).  Synthesis of novel cyclic NGR/RGD peptide analogs via on resin click chemistry. Bioorg Med Chem Lett. Dec 15;20(24):7337-40. Epub 2010 Oct 21.

 

  1. Kohler ME, Johnson BD, Palen K, Chen QR, Khan J, Orentas RJ.  (2010) Systematic Tumor antigen analysis in neuroblastoma by serological interrogation of bioinformatic data.  Cancer Sci. 2010 Nov;101(11):2316-24. doi: 10.1111/j.1349-7006.2010.01694.x.

 

51. Kohler ME, Hallett WH, Chen QR, Khan J, Johnson BD, Orentas RJ.  (2010) Early expression of stem cell-associated genes within the CD8 compartment after treatment with a tumor vaccine.  Cell Immunol. 2010;265(1):65-73. Epub 2010 Jul 17.

 

52. Liu Z, Yang X, Li Z, McMahon C, Sizer C, Barenboim-Stapleton L, Bliskovsky V, Mock B, Ried T, London WB, Maris J, Khan J, Thiele CJ  (2011)  CASZ1, a candidate tumor-suppressor gene, suppresses neuroblastoma tumor growth through reprogramming gene expression.  Cell Death Differ. 2011 Jan 21. [Epub ahead of print].

 

53. Gonzalez-Bosquet J, Calcei J, Wei JS, Garcia-Closas M, Sherman ME, Hewitt S, Vockley J, Lissowska J, Yang HP, Khan J, Chanock S. (2011)  Detection of Somatic Mutations by High-Resolution DNA Melting (HRM) Analysis in Multiple Cancers.  PLoS One. 2011 Jan 17;6(1):e14522.

 

54. Rubin BP, Nishijo K, Chen HI, Yi X, Schuetze DP, Pal R, Prajapati SI, Abraham J, Arenkiel BR, Chen QR, Davis S, McCleish AT, Capecchi MR, Michalek JE, Zarzabal LA, Khan J, Yu Z, Parham DM, Barr FG, Meltzer PS, Chen Y, Keller C  (2011)  Evidence for an unanticipated relationship between undifferentiated pleomorphic sarcoma and embryonal rhabdomyosarcoma.  Cancer Cell. 2011 Feb 15;19(2):177-91.

 

55. Grohar PJ, Griffin LB, Yeung C, Chen QR, Pommier Y, Khanna C, Khan J, Helman LJ. (2011)  Ecteinascidin 743 interferes with the activity of EWS-FLI1 in Ewing sarcoma cells.  Neoplasia. 2011 Feb;13(2):145-53.

 

56. Briggs J, Paoloni M, Chen QR, Wen X, Khan J, Khanna C. (2011)  A compendium of canine normal tissue gene expression.  PLoS One. 2011;6(5):e17107. Epub 2011 May 31

 

57. Grohar PJ, Woldemichael GM, Griffin LB, Mendoza A, Chen QR, Yeung C, Currier DG, Davis S, Khanna C, Khan J, McMahon JB, Helman LJ. (2011)  Identification of an inhibitor of the EWS-FLI1 oncogenic transcription factor by high-throughput screening.  J Natl Cancer Inst. 2011 Jun 22;103(12):962-78. doi: 10.1093/jnci/djr156. Epub 2011 Jun 8.

 

58. Meadors JL, Cui Y, Chen QR, Song YK, Khan J, Merlino G, Tsokos M, Orentas RJ, Mackall CL. (2011)  Murine rhabdomyosarcoma is immunogenic and responsive to T-cell-based immunotherapy.  Pediatr Blood Cancer. 2011 Dec 1;57(6):921-9. doi: 10.1002/pbc.23048. Epub 2011 Apr 1.

 

59. Xiang Guo, Qing-Rong Chen, Young K Song1, Jun S. Wei, Javed Khan. (2011)  Exon array analysis reveals neuroblastoma tumors have distinct alternative splicing patterns according to stage and MYCN amplification status.  BMC Med Genomics. 2011 Apr 18;4:35.

 

60. Hsu AP, Sampaio EP, Khan J, Calvo KR, Lemieux JE, Patel SY, Frucht DM, Vinh DC, Auth RD, Freeman AF, Olivier KN, Uzel G, Zerbe CS, Spalding C, Pittaluga S, Raffeld M, Kuhns DB, Ding L, Paulson ML, Marciano BE, Gea-Banacloche JC, Orange JS, Cuellar-Rodriguez J, Hickstein DD, Holland SM. (2011)  Mutations in GATA2 are associated with the autosomal dominant and sporadic monocytopenia and mycobacterial infection (MonoMAC) syndrome.  Blood. 2011 Sep 8;118(10):2653-5. Epub 2011 Jun 13.

 

  1. Wang C, Liu Z, Woo CW, Li Z, Wang L, Wei JS, Marquez VE, Bates SE, Jin Q, Khan J, Ge K, Thiele CJ. (2012)  EZH2 Mediates epigenetic silencing of neuroblastoma suppressor genes CASZ1, CLU, RUNX3, and NGFR. Cancer Res. 2012 Jan 1;72(1):315-24. Epub 2011 Nov 8.

 

  1. Tsang PS, Cheuk AT, Chen QR, Song YK, Thomas BC, Wei JS, Khan J. (2012) Synthetic Lethal Screen Identifies NF-kappaB as a Target for Combination Therapy with Topotecan for Patients with Neuroblastoma. BMC Cancer. 2012 Mar 21;12(1):101.

 

  1. Ren L, Hong SH, Chen QR, Briggs J, Cassavaugh J, Srinivasan S, Lizardo MM, Mendoza A, Xia AY, Avadhani N, Khan J, Khanna C.. (2012) Dysregulation of ezrin phosphorylation prevents metastasis and alters cellular metabolism in osteosarcoma. Cancer Res. 2012 Feb 15;72(4):1001-12. Epub 2011 Dec 6.

 

  1. Briggs JW, Ren L, Nguyen R, Chakrabarti K, Cassavaugh J, Rahim S, Bulut G, Zhou M, Veenstra TD, Chen Q, Wei JS, Khan J, Uren A, Khanna C (2012) The ezrin metastatic phenotype is associated with the initiation of protein translation. Neoplasia. 2012 Apr;14(4):297-310.

 

  1. Stauffer JK, Orentas RJ, Lincoln E, Khan T, Salcedo R, Hixon JA, Back TC, Wei JS, Patidar R, Song Y, Hurd L, Tsokos M, Lai EW, Eisenhofer G, Weiss W, Khan J, Wigginton JM. (2012) High-throughput molecular and histopathologic profiling of tumor tissue in a novel transplantable model of murine neuroblastoma: new tools for pediatric drug discovery. Cancer Invest. 2012 Jun;30(5):343-63.

 

  1. Wan X, Yeung C, Kim SY, Dolan JG, Ngo VN, Burkett S, Khan J, Staudt LM, Helman LJ. (2012) Identification of FoxM1/Bub1b Signaling Pathway as a Required Component for Growth and Survival of Rhabdomyosarcoma. Cancer Res. 2012 Nov 15;72(22):5889-99. doi: 10.1158/0008-5472.CAN-12-1991. Epub 2012 Sep 20.

 

  1. Schleiermacher G, Mosseri V, London WB, Maris JM, Brodeur GM, Attiyeh E, Haber M, Khan J, Nakagawara A, Speleman F, Noguera R, Tonini GP, Fischer M, Ambros I, Monclair T, Matthay KK, Ambros P, Cohn SL, Pearson AD. (2012) Segmental chromosomal alterations have prognostic impact in neuroblastoma: a report from the INRG project. Br J Cancer. 2012 Oct 9;107(8):1418-22. doi: 10.1038/bjc.2012.375. Epub 2012 Sep 13.

 

  1. Zhou Q, Lee GS, Brady J, Datta S, Katan M, Sheikh A, Martins MS, Bunney TD, Santich BH, Moir S, Kuhns DB, Long Priel DA, Ombrello A, Stone D, Ombrello MJ, Khan J, Milner JD, Kastner DL, Aksentijevich I. (2012) A hypermorphic missense mutation in PLCG2, encoding phospholipase Cγ2, causes a dominantly inherited autoinflammatory disease with immunodeficiency. Am J Hum Genet. 2012 Oct 5;91(4):713-20. doi: 10.1016/j.ajhg.2012.08.006. Epub 2012 Sep 20.

 

  1. Orentas RJ, Yang JJ, Wen X, Wei JS, Mackall CL, Khan J. (2012) Identification of cell surface proteins as potential immunotherapy targets in 12 pediatric cancers. Front Oncol. 2012;2:194. doi: 10.3389/fonc.2012.00194. Epub 2012 Dec 17.

 

  1. Yeung CL, Ngo VN, Grohar PJ, Arnaldez FI, Asante A, Wan X, Khan J, Hewitt SM, Khanna C, Staudt LM, Helman LJ. (2013) Loss-of-function screen in rhabdomyosarcoma identifies CRKL-YES as a critical signal for tumor growth. Oncogene. 2013 Jan 14. doi: 10.1038/onc.2012.590.

 

  1. Pugh TJ, Morozova O, Attiyeh EF, Asgharzadeh S, Wei JS, Auclair D, Carter SL, Cibulskis K, Hanna M, Kiezun A, Kim J, Lawrence MS, Lichenstein L, McKenna A, Pedamallu CS, Ramos AH, Shefler E, Sivachenko A, Sougnez C, Stewart C, Ally A, Birol I, Chiu R, Corbett RD, Hirst M, Jackman SD, Kamoh B, Khodabakshi AH, Krzywinski M, Lo A, Moore RA, Mungall KL, Qian J, Tam A, Thiessen N, Zhao Y, Cole KA, Diamond M, Diskin SJ, Mosse YP, Wood AC, Ji L, Sposto R, Badgett T, London WB, Moyer Y, Gastier-Foster JM, Smith MA, Auvil JM, Gerhard DS, Hogarty MD, Jones SJ, Lander ES, Gabriel SB, Getz G, Seeger RC, Khan J, Marra MA, Meyerson M, Maris JM (2013) The genetic landscape of high-risk neuroblastoma. Nat Genet. 2013 Mar;45(3):279-84. doi: 10.1038/ng.2529. Epub 2013 Jan 20.

 

  1. Zhang H, Maric I, Diprima MJ, Khan J, Orentas RJ, Kaplan RN, Mackall CL (2013) Fibrocytes represent a novel MDSC subset circulating in patients with metastatic cancer. Blood. 2013 Jun 11.

 

  1. Abdul-Karim R, Berkman BE, Wendler D, Rid A, Khan J, Badgett T, Hull SC. (2013) Disclosure of incidental findings from next-generation sequencing in pediatric genomic research. Pediatrics. 2013 Mar;131(3):564-71. doi: 10.1542/peds.2012-0084. Epub 2013 Feb 11. Review. Erratum in: Pediatrics. 2013 Jul;132(1):172.

 

  1. Patel PR, Sun H, Li SQ, Shen M, Khan J, Thomas CJ, Davis MI (2013) Identification of potent Yes1 kinase inhibitors using a library screening approach. Bioorg Med Chem Lett. 2013 Aug 1;23(15):4398-403. doi: 10.1016/j.bmcl.2013.05.072. Epub 2013 May 29.

 

  1. Wei JS, Johansson P, Chen L, Song YK, Tolman C, Li S, Hurd L, Patidar R, Wen X, Badgett TC, Cheuk AT, Marshall JC, Steeg PS, Vaqué Díez JP, Yu Y, Gutkind JS, Khan J (2013) Massively parallel sequencing reveals an accumulation of de novo mutations and an activating mutation of LPAR1 in a patient with metastatic neuroblastoma.(2013). PLoS One. 2013 Oct 16;8(10):e77731. doi: 10.1371/journal.pone.0077731.

 

  1. Li SQ, Cheuk AT, Shern JF, Song YK, Hurd L, Liao H, Wei JS, Khan J.(2014) Targeting wild-type and mutationally activated FGFR4 in rhabdomyosarcoma with the inhibitor ponatinib (AP24534). PLoS One. 2013 Oct 4;8(10):e76551. doi: 10.1371/journal.pone.0076551.

 

  1. Shern JF, Chen L, Chmielecki J, Wei JS, Patidar R, Rosenberg M, Ambrogio L, Auclair D, Wang J, Song YK, Tolman C, Hurd L, Liao H, Zhang S, Bogen D, Brohl AS, Sindiri S, Catchpoole D, Badgett T, Getz G, Mora J, Anderson JR, Skapek SX, Barr FG, Meyerson M, Hawkins DS, Khan J. (2014) Comprehensive genomic analysis of rhabdomyosarcoma reveals a landscape of alterations affecting a common genetic axis in fusion-positive and fusion-negative tumors. Cancer Discov. 2014 Feb;4(2):216-31. doi: 10.1158/2159-8290.CD-13-0639. Epub 2014 Jan 23.

 

  1. Shah N, Wang J, Selich-Anderson J, Graham GT, Siddiqui H, Li X, Khan J, Toretsky JA (2014) PBX1 is a Favorable Prognostic Biomarker as it Modulates 13-cis Retinoic Acid-mediated Differentiation in Neuroblastoma. (2014). Clin Cancer Res. 2014 Jun 19.

 

  1. Brohl AS, Solomon DA, Chang W, Wang J, Song Y, Sindiri S, Patidar R, Hurd L, Chen L, Shern JF, Liao H, Wen X, Gerard J, Kim JS, Lopez Guerrero JA, Machado I, Wai DH, Picci P, Triche T, Horvai AE, Miettinen M, Wei JS, Catchpool D, Llombart-Bosch A, Waldman T, Khan J.  (2014) The Genomic Landscape of the Ewing Sarcoma Family of Tumors Reveals Recurrent STAG2 Mutation. (2014). PLoS Genet. 2014 Jul 10;10(7):e1004475. doi: 10.1371/journal.pgen.1004475. eCollection 2014 Jul.

 

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